Pyrazolylquinazolinones as potassium channel openers

Details Pyrazolylquinazolinones as potassium channel openers Pyrazolylquinazolinones as potassium channel openers

2007-02-16

2011-11-08

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S284000

Reexamination Certificate

active

08053441

ABSTRACT:
The present invention is directed to novel pyrazolylquinazolinone derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.

REFERENCES:
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patent: WO 2006/097441 (2006-09-01), None
Soliman, E.A. “Some reactions of 2-[3- (3,4-dichlorophenyl) -2- pyrazoline-5-yl] -4H- benzoxazin -4- one”, Chemical Abstract, 1981, vol. 95, Abstract No. 19377a, or 19380a.
Soliman, E.A. “Some reactions of 2-[3- (3,4-dichlorophenyl) -2- pyrazoline-5-yl] -4H- benzoxazin -4- one”, Revue Roumaine de Chimie, (1981), vol. 26, No. 5, pp. 699-703.
Miller, T.R., “Pharmacological and molecular characterization of ATP-sensitive K+ channels . . . ” European Journal of Pharmacology, vol. 370, No. 2, Apr. 9, 1999, pp. 179-185 (only abstract provided).
PCT International Search Report for International Application No. PCT/US2007/062287 dated Jul. 3, 2007.
Wein, A.J.: “Overactive Bladder: Defining the Disease”; The American J. of Managed Care vol. 6, No. 11 (2000): S559-564.

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