Substance having antioxidant, geroprotective and...

Details Substance having antioxidant, geroprotective and... Substance having antioxidant, geroprotective and...

2008-12-18

2011-10-25

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S277000

Reexamination Certificate

active

08044210

ABSTRACT:
The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic in solution of a lower alcohol at a temperature of 60-100° C. with following treatment of the reaction mass with an organic solvent and maintaining for 2-5 h at 10-15 ° C.

REFERENCES:
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Physical Characterization of Pharmaceutical Solids, 1995, V. 70, p. 344.
Brittain, H. G., Physical Characterization of Pharmaceutical Solids, Drugs and the Pharmaceutical Sciences, vol. 70, p. 344, 1995.
Hcaplus 1970:486385 Abstract, “Kinetic characteristics of synthetic inhibitors and their relation to antitumoral action”, Khrapova, N. G., 1970.
Wijtmans, J. Org. Chem. 2004, vol. 69, pp. 9215-9223.
M.D. Mashkovsky, “Pharmaceuticals”, part II, 1993, Moscow, Medicine, p. 216.

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