Tricyclic pyrazole derivatives as cannabinoid receptor...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S011000

Reexamination Certificate

active

08030345

ABSTRACT:
The present invention relates to novel compounds of general formula (I),their regioisomers, tautomeric forms, novel intermediates involved in their synthesis. The present invention also relates to a process of preparing compounds of general formula (I), their regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

REFERENCES:
patent: 01/32629 (2001-05-01), None
patent: 01/32663 (2001-05-01), None
Wermuth. The Practice of Medicinal Chemistry, 1996, pp. 203-237.
Grant et al. Clinical Neuroscience Research, 2005, 5, 185-199.
U.S. Appl. No. 12/769,861, filed Apr. 2010, Lohray.
Stoit, A. R.,et al. “Design, Synthesis and Biological Activity of Rigid Cannabinoid CB1Receptor Antagonists.”Chem Pharm. Bull(2002) vol. 50, No. 8, pp. 1109-1113.
Ruiu, S., et al. Synthesis and Characterization of NESS 0327: A Novel Putative Antagonist of the CB1Cannabinoid Receptor.:The Journal of Pharmacology and Experimental Therapeutics(2003) vol. 306, No. 1, pp. 363-370.
Fravolina, A., et al. “Synthesis and pharmacological activity of benzothiopyranopyrazole and benzothiopyranoisoxazole and benzothi opyranoisoxazole carboxamides.”FARMACO, Edizione Scientifica, Societa Chimica Italinana, Pavia, It.(1978) vol. 33, No. 11, pp. 855-865.
Mussinu, J-M., et al. “Tricyclic Pyrazoles. Part 1: Synthesis and Biological Evaluation of Novel 1,4-Dihydroindeno[1,2-c]pyrazol-based Ligands for CB1and CB2Cannabinoid Receptors.”Bioorganic&Medicinal Chemistry(2003) vol. 11, pp. 251-263.

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