Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2007-05-10
2011-11-22
McCormick, Melenie (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C514S415000, C549S409000
Reexamination Certificate
active
08062679
ABSTRACT:
A composition comprising at least a therapeutically effective amount of L-carnitine fumarate, and an extract ofColeus forskohliiis provided to maintain androgen and androgen-like uptake potential in cells, via simultaneous increase in the availability of androgen receptors and improved availability of androgen and androgen-like molecules. A method of same is also provided. The present invention further comprises therapeutically effective amounts of one or more of N-acetyl L-carnitine, melatonin. ubidecarenone (coenzyme Q10), idebenone, decylubiquinone, an extract ofAgaricus blazei Murill, and ginsenoside Rb1.
REFERENCES:
patent: 5804596 (1998-09-01), Majeed et al.
patent: 2004/0005368 (2004-01-01), Mann et al.
patent: 2005/0095233 (2005-05-01), McCleary et al.
patent: 2005/0238654 (2005-10-01), Takeda
patent: 2006/0051435 (2006-03-01), Udell et al.
patent: 9702041 (1997-01-01), None
Prunet-Marcassus et al. Melatonin Reduces Body Weight Gain in Sprague Dawley Rats With Diet Induced Obesity. Endocrinology. 144 (12): 5347-5352.
Idebenone. Alternative Medicine Review. vol. 6, No. 1. 2001. pp. 83-36.
Armstrong et al. The Coenzyme Q 10 Analog Decylubiquinone Inhibits the Redox-Activated Mitochondrial Permeability Transition. The Journal of Biological Chemistry. vol. 278, No. 49 Dec. 5, 2003. pp. 49079-49084.
Hu et al. Hepatoprotective Effet of Ginsenoside RB1 and Compound K on Tert-Butyl Hydroperoxide-Induced Liver Injury. Liver International. 25. 2005. 1069-1073.
Wu et al. Quality Evaluation of the Commercial Ginsengs by High-Performance Liquid Chromatography. Yixue Yanjiu (1993), 14, (1). English Abstract.
Kraemer WJ, et al. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc. Jul. 2006;38(7):1288-96.
Inoue K, et al. Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle. Eur J Appl Physiol Occup Physiol. 1994;69(1):88-91.
Deschenes MR, et al. Endurance and resistance exercise induce muscle fiber type specific responses in androgen binding capacity. J Steroid Biochem Mol Biol. Aug. 1994;50(3-4):175-9.
Bamman MM, et al. Mechanical load increases muscle IGF-I and androgen receptor mRNA concentration in humans. Am J Physiol Endocrinol Metab. Mar. 2001;280(3):E383-90.
Willoughby DS, et al. Effects of sequential bouts of resistance exercise on androgen receptor expression. Med Sci Sports Exerc. Sep. 2004;36(9):1499-506.
Ratamess NA, et al. Androgen receptor content following heavy resistance exercise in men. J Steroid Biochem Mol Biol. Jan. 2005:93(1):35-42.
Kraemer WJ, et al. The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond Res. Aug. 2003;17(3):455-62.
Volek JS, et al. L-carnitine L-tartrate supplementation favorably affect markers of recovery from exercise stress. Am J Physiol Endocrinol Metab. Feb. 2002;282(2):E474-82.
Giamberardino MA, et al. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effect. Int J Sports Med. Jul. 1996;17(5):320-4.
Godard MP, et al. Body composition and hormonal adaptations associated with forskolin consumption in overweigh and obese men. Obes Res. Aug. 2005;13(8):1335-43.
Mackay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev. Mar. 2004;9(1):4-16.
Giuliano F, et al. Alpha receptors in the central nervous system and its effects on erection. J Androl. 1999;20:683-7.
Guay AT, et al. Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial. Int J Impot Res. Feb. 2002;14(1):25-31.
Forsling ML, et al. The effect of melatonin administration on pituitary hormone secretion in man. Clin Endocrinol (Oxf). Nov. 2002;57(5):615-20.
Vanhelder WP, et al. Growth hormone responses during intermittent weight lifting exercise in men. Eur J Appl Physiol Occup Physiol. 1984;53(1):31-4.
Goto K, et al. A single set of low intensity resistance exercise immediately following high intensity resistance exercise stimulates growth hormone secretion in men. J Sports Med Phys Fitness. Jun. 2003;43(2):243.
Meeking DR, et al. Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects. Eur J Endocrinol. Jul. 1999;141(1):22-6.
Nassar E, et al. Effects of prophylactic N-Acetyl-5-methoxytryptamine (melatonin) supplementation and resistance exercise on serum growth hormone levels and the hypothalamus-pituitary-adrenal axis in young males and females. J Int Soc Sports Nutr 2006;3(1):S1-29 (Poster 24).
Weber C, et al. Antioxidative effect of dietary coenzyme Q10 in human blood plasma. Int J Vitam Nutr Res. 1994;64(4):311-5.
Thomas SR, et al. Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in Atherogenesis? Mol Aspects Med. 1997;18 Suppl:S85-103.
Kamikawa T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol. Aug. 1, 1985;56(4):247-51.
Folkers K, et al. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proc Natl Acad Sci USA. Jul. 1985;82(13):4513-6.
Idebenone—Monograph. Altern Med Rev. Feb. 2001;6(1):83-6.
Armstrong JS, et al. The coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition. J Biol Chem. Dec. 5, 2003;278(49):49079-84.
Liu J, et al. Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis. J Biol Chem. 2006 Dex 15;281(50):38879-93.
Chen S, et al. Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). Cancer Res. Dec. 15, 2006;66(24):12026-34 (Abstract).
Tsai SC, et al. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Chin J Physiol. Mar. 2003;46(1):1-7 (Abstract).
PCT International Application No. PCT/CA2007/000835 filed May 10, 2007, International Search Report dated Feb. 12, 2008, Applicant: Multi Formulations Ltd. et al.
Saper et al., “Common Dietary Supplements for Weight Loss”, American Family Physician, vol. 70-No. 9, pp. 1731-1738. (2004).
Zhang et al., “Antiangiogenic Effect of Capecitabine Combined with Ginsenoside Rg3 . . . ”, Cancer Biotherapy & Radiopharmaceuticals, vol. 23, No. 5, pp. 647-653 (2008).
Kraemer, W.J. et al., The Effects of L-caritine L-tartrate Supplementation on Hormonal Responses to Resistance Exercise and Recovery, Journal of Strength and Conditioning Research, 2003, 17(3):455-462, ISSN: 1064-8011.
Kraemer, W.J. et al., Androgenic Responses to Resistance Exercise: Effects of Feeding and L-Carnitine, Medicine and Science in Sports and Exercise, Jul. 2006, 38(7): 1288-1296, ISSN: 0195-9131.
Ariga, T., The antioxidative function, preventive action on disease and utilization of proanthocyanidins, Biofactors, 2004, 21(1-4): 197-201, ISSN: 0951-6433.
Brown, G.A. et al., Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men, International Journal of Sport Nutrition and Exercise Metabolism, 2000, 10 (3):340-359, ISSN: 1526-484X.
International Search Report by ISA/CA dated Aug. 27, 2008, PCT International Application No. PCT/CA2008/000880 filed May 12, 2008, Applicant: Multi Formulations Ltd et al.
Apong Phil
Chaudhuri Shan
Clement Ken
Molino Michele
McCormick Melenie
Northern Innovations and Formulations Corp.
LandOfFree
Composition for maintaining androgen and androgen-like... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition for maintaining androgen and androgen-like..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for maintaining androgen and androgen-like... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4284927