Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2006-04-13
2011-10-18
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
active
08039617
ABSTRACT:
A method for selectively producing stable alpha form crystals of sapropterin hydrochloride is provided. In this method, the alpha form crystal of sapropterin hydrochloride is produced by dissolving sapropterin hydrochloride with hydrochloric acid at a concentration of not less than 4 mol/L at not less than 70 degrees C.; adding heated ethanol to the solution; and cooling the solution at a cooling rate of not faster than 3 degrees C./min to a temperature of 40 to 55 degrees C. to precipitate the crystals.
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Schircks, et al., “Herstellung von (6 R, S)-5,6,7,8-Tetrahydro-L-biopterin, 7,8-Dihydro-L-biopterin, L-Sepiapterin, Deoxysepiapterin, (6 R, S)-5,6-Dihydrodeoxysepiapterin und 2′-Deoxybiopterin1)”, Helvetica Chimica Acta, vol. 61, No. 7, pp. 2731-2738, XP-002391645, 1978.
Hotoda Katsumi
Kiyono Hiroomi
Tazawa Shinnosuke
Daiichi Sankyo Company, Limited
Jaisle Cecilia M
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
Shiratori Pharmaceutical Co., Ltd.
Wilson James O
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