Compositions and methods for inhibiting cell migration

Details Compositions and methods for inhibiting cell migration Compositions and methods for inhibiting cell migration

2010-11-01

2011-10-18

Monshipouri, Maryam (Department: 1656)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

Reexamination Certificate

active

08039255

ABSTRACT:
The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human breast cancers correlates with indicators of outcome: Dkk1 associates with markers of poor prognosis whereas expression of single function Dkk2 or Dkk3 (which inhibit Wnt/β-catenin signaling and promote migration, respectively) correlates with phenotypes reflective of good prognosis. Therefore, the pro-migratory activities of Dkk1 and 3 identified here offer new insights into breast cancer progression and a potential avenue for therapeutic intervention.

REFERENCES:
patent: 2004/0014209 (2004-01-01), Lassar et al.
patent: WO 98/46755 (1998-10-01), None
Brott and Sokol, “Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkoft Proteins,”Mol. Cell. Biol. (2002), 22(17):6100-6110, American Society for Microbiology.
Glinka et al., “Dickkopf-1 is a Member of a New Family of Secreted Proteins and Functions in Head Induction,”Nature(1998), 391:357-362, Macmillan Publishers Ltd.
Krupnik et al., “Functional and Structural Diversity of the Human Dickkopf Gene Family,”Gene(1999), 238:301-313, Elsevier Science B.V.
Lee et al., “Dickkopf-1 Antagonizes Wnt Signaling Independent of β-Catenin in Human Mesothelioma,”Biochem. Biophys. Res. Commun. (2004), 323:1246-1250, Elsevier Inc.
Li et al., “Second Cysteine-Rich Domain of Dickkopt-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled,”J. Biol. Chem. (2002) 277(8):5977-5981.
Mao and Niehrs, “Kremen2 Modulates Dickkopf2 Activity During Wnt/LRP6 Signaling,”Gene(2003), 302:179-183, Elsevier Science B.V.
Monaghan et al., “DickkopfGenes are Co-ordinately Expressed in Mesodermal Lineages,”Mech. Dev. (1999), 87:45-56, Elsevier Science Ireland Ltd.

Affiliated with

Also associated with

Rating

Compositions and methods for inhibiting cell migration does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for inhibiting cell migration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inhibiting cell migration will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4278509