Multiplex data collection and analysis in bioanalyte detection

Details Multiplex data collection and analysis in bioanalyte detection Multiplex data collection and analysis in bioanalyte detection

2008-06-26

2011-11-22

Whisenant, Ethan C (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C536S023100, C536S024300, C530S350000

Reexamination Certificate

active

08062841

ABSTRACT:
Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a single spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.

REFERENCES:
patent: 4245171 (1981-01-01), Rabinowitz et al.
patent: 4444879 (1984-04-01), Foster et al.
patent: 5635352 (1997-06-01), Urdea et al.
patent: 5766963 (1998-06-01), Baldwin et al.
patent: 5925517 (1999-07-01), Tyagi et al.
patent: 6238868 (2001-05-01), Carrino et al.
patent: 6514767 (2003-02-01), Natan
patent: 6852492 (2005-02-01), Berlin et al.
patent: 6861263 (2005-03-01), Natan
patent: 6970239 (2005-11-01), Chan et al.
patent: 7361410 (2008-04-01), Zhang et al.
patent: 2002/0074342 (2002-06-01), Shafer
patent: 2002/0090662 (2002-07-01), Ralph
patent: 2002/0197603 (2002-12-01), Chow et al.
patent: 2003/0032035 (2003-02-01), Chatelain et al.
patent: 2003/0129611 (2003-07-01), Bao et al.
patent: 2003/0224457 (2003-12-01), Hurt et al.
patent: 2004/0046121 (2004-03-01), Golden et al.
patent: 2004/0053237 (2004-03-01), Liu et al.
patent: 2004/0086897 (2004-05-01), Mirkin et al.
patent: 2004/0142484 (2004-07-01), Berlin et al.
patent: 2004/0152200 (2004-08-01), Deshmukh
patent: 2004/0175490 (2004-09-01), Stahler et al.
patent: 2005/0064432 (2005-03-01), Huang et al.
patent: 2005/0064435 (2005-03-01), Su et al.
patent: 2005/0064604 (2005-03-01), Bohmann et al.
patent: 2005/0123974 (2005-06-01), Gilmanshin et al.
patent: 2005/0130163 (2005-06-01), Smith et al.
patent: 2005/0147976 (2005-07-01), Su
patent: 2005/0147977 (2005-07-01), Koo et al.
patent: 2005/0151966 (2005-07-01), Packirisamy et al.
patent: 2005/0196876 (2005-09-01), Chan et al.
patent: 2006/0033910 (2006-02-01), Sun et al.
patent: 2006/0057576 (2006-03-01), Paszkowski et al.
patent: 2007/0117212 (2007-05-01), Kautz et al.
patent: 2007/0279626 (2007-12-01), Sun et al.
patent: 2008/0146791 (2008-06-01), Stahler et al.
Ebata et al., Nucleic acid hybridization accompanied with excimer formation from two pyrene-labeled probes. Photochemistry and Photobiology 62 (5) :836-839 (1995).
Peytavi et al. Microfluidic Device for Rapid (<15 min) Automated Microarray Hybridization. Clinical Chemistry 51 : 10: 1836-1844 (Published online on Aug. 17, 2005).
Wang et al., Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate for the detection of low-adundant DNA mutations. Analytical Chemistry 75 :1130-1140 (2003).
Su, et al., 2005. “Composite Organic-Inorganic Nanoparticles (COINs) with Chemically Encoded Optical Signatures”. NANO Letters 5(1): 49-54.
Wang, et al., 2003. “Microarrays Assembled in Microfluidic Chips Fabricated From Poly(methyl methacrylate) for the Detection of Low-abundant DNA Mutations”. Analytical Chemistry 75: 1130-1140.
Han, et al., 2001. “Quantum-Dot-Tagged Microbeads for Multiplexed Optical Coding of Biomolecules”. Nature Biotechnology 19: 631-635.
Non-Final Office Action, mailed Jul. 2, 2007, U.S. Appl. No. 11/026,857, filed Dec. 30, 2004, First Named Inventor: Xing Su.
Non-Final Office Action, mailed Jun. 29, 2007, U.S. Appl. No. 11/027,470, filed Dec. 30, 2004, First Named Inventor: Mark Roth.

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