Pharmaceutical compositions for transdermal delivery

Details Pharmaceutical compositions for transdermal delivery Pharmaceutical compositions for transdermal delivery

2005-11-03

2011-11-29

Tsang, Cecilia J (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S328000, C514S016600, C424S193100

Reexamination Certificate

active

08067376

ABSTRACT:
The present invention relates to a pharmaceutical composition for transdermal administration comprising a conjugate of methotrexate and PTD (protein transduction domain). In accordance with the present invention, the methotrexate, which is widely used for the treatment of psoriasis, rheumatoid and inflammation, etc., can be delivered transdermally to a local part of a patient body, in order to minimize the side effect of the methotrexate.

REFERENCES:
patent: 6485740 (2002-11-01), Tominaga et al.
patent: 2006/0293242 (2006-12-01), Temsamani et al.
patent: 10-2004-0088568 (2004-10-01), None
patent: 00/29427 (2000-05-01), None
patent: WO-00/64486 (2000-11-01), None
patent: 01/62297 (2001-08-01), None
patent: WO-03/059941 (2003-07-01), None
patent: WO-03059940 (2003-07-01), None
patent: WO-03059941 (2003-07-01), None
patent: WO-03/074551 (2003-09-01), None
patent: WO-2004013160 (2004-02-01), None
Alvarez-Figueroa et al.; “Transdermal delivery of methotrexate: iontophoretic delivery from hydrogels and passive delivery from micromuolsions” In: International Journal of Pharmaceutics; 2001, 215(1-2); pp. 57-65.
Alvarez-Figueroa et al.; “Passive and iontophoretic transdermal penetration of methotrexate” In: International Journal of Pharmaceutics; 2001, 212(I); pp. 101-107.
Kabouridis, P.S., “Biological applications of protein transduction technology,” TRENDS in Biotechnology, vol. 21, No. 11 (Nov. 2003).
Mait, J.C. et al., “Efficiency of Protein Transduction Is Cell Type-dependent and Is Enchanced by Destran Sulfate,” The Journal of Biological Chemistry, vol. 377, pp. 30208-30218, 2002.
Shen, Wei-Chiang et al., “Poly (L-Lysine) and Poly (D-Lysine) Conjugates of Methotrexate: Different Inhibitory Effect on Drug Resistant Cells,” Molecular Pharmacology, 16, pp. 614-622, 1979.
Official Action for Japanese Patent Application No. 2007-540252, issued Jan. 11, 2011.

Affiliated with

Also associated with

Rating

Pharmaceutical compositions for transdermal delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical compositions for transdermal delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions for transdermal delivery will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4268374