Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2008-11-14
2011-11-22
Puttlitz, Karl J (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C560S122000, C562S503000, C562S504000, C514S573000
Reexamination Certificate
active
08063240
ABSTRACT:
A prostaglandin analog with selectivity to EP receptors and demonstrating EP agonist activity that may be used to expand hematopoietic stem cell populations or to treat or prevent influenza, bone fracture, bone disease, glaucoma, ocular hypertension, dysmenorrhoea, pre-term labor, immune disorders, osteoporosis, asthma, allergy, male sexual dysfunction, female sexual dysfunction, periodontal disease, gastric ulcer, renal disease, or other EP receptor-mediated conditions.
REFERENCES:
patent: 3886206 (1975-05-01), Crabbe et al.
patent: 4138590 (1979-02-01), Kao
patent: 5576347 (1996-11-01), Sredni et al.
patent: 6426359 (2002-07-01), Cameron et al.
patent: 6476064 (2002-11-01), Old et al.
patent: 6562868 (2003-05-01), Stjernschantz et al.
patent: 6894175 (2005-05-01), DeLong
patent: 7326732 (2008-02-01), Oxford et al.
patent: 2002/0177620 (2002-11-01), Burk et al.
patent: 2007/0112067 (2007-05-01), Garvey et al.
patent: 98/34916 (1998-08-01), None
patent: 00/31084 (2000-06-01), None
patent: 00/40248 (2000-07-01), None
patent: 01/46140 (2001-06-01), None
patent: 03/037433 (2003-05-01), None
patent: 03/040126 (2003-05-01), None
patent: 2007/027468 (2007-03-01), None
patent: 2008/073748 (2008-06-01), None
“Crystallization” in Kirk-Othmer Encyclopedia of Chemical Technology Copyright © 2002 by John Wiley & Sons, Inc., pp. 95-147, Article Online Posting Date: Aug. 16, 2002.
Rouhi, “The Right Stuff, from research and development to the clinic, getting drug crystals right is full of pitfalls”, Chemical & Engineering News, Feb. 24, 2003, pp. 32-35.
Ullmann's Encyclopedia of Industrial Chemistry, Copyright © 2002 by Wiley-VCH Verlag GmbH & Co. KGaA , pp. 1-51.
Breyer et al., “Structure-Function Analyses of Eicosanoid Receptors”, Annals of New York Academy of Sciences, 905, (2000), pp. 221-231.
Klimko et al., “15-Fluoro Prostaglandin FP Agonists: A New Class of Topical Ocular Hypotensives”, Bioorganic & Medicinal Chemistry 12 (2004), pp. 3451-3469.
Matsumara et al., “Novel Fluoroprostacyclin Analogs with Modified Cycloalkylenyl Chains. Highly Potent and Orally Active Anti-Aging Agents”, Chem. Pharm. Bull 43(2), (1995), pp. 353-355U.
Waterbury et al., “EP3 But Not EP2, FP, or TP Prostanoid-Receptor Stimulation May Reduce Intraocular Pressure”, Investigative Opthalmology & Visual Science, vol. 31, No. 12, Dec. 1990, pp. 2560-2567.
Li et al., “A Novel, Non-Prostanoid EP2 Receptor-Selective Prostaglandin E2 Agonist Stimulates Local Bone Formation and Enhances Fracture Healing”, Journal of Bone and Mineral Research, vol. 18, No. 11, 2003, pp. 2033-2042.
Grieco et al., “Fluoroprostaglandins: Total Synthesis of (+)-13-Fluoroprostaglandin F2alpha Methyl Ester”, Journal of Organic Chemistry, 50, (1985), pp. 3111-3115.
North et al., “Prostaglandin E2 Regulates Vertebrate Haematopoietic Stem Cell Homeostasis,” Nature, vol. 447, Jun. 21, 2007, pp. 1007-1011.
Paralkar et al., “An EP2 Receptor-Selective Prostaglandin E2 Agonist Induces Bone Healing,” Proceedings of the National Academy of Sciences, vol. 100, No. 11, May 27, 2003, pp. 6736-6740.
Asai et al., “Synthesis of New Stable Fluoroprostacyclin Analogs with Potent Anti-Anginal Activity”, Tetrahedron Letters, vol. 36, No. 2, (1995), pp. 273-276.
Matsumura et al., “Synthesis of the Highly Potent Prostanoid FP Receptor Agonist, AFP-168: a novel 15-deoxy-15, 15-difluoroprostaglandin F2alpha Derivative”, Tetrahedron Letters 45 (2004), pp. 1527-1529.
Matsumura et al., “Synthesis of 7-Fluoro-2, 4-methylene-17, 20-dimethylprostacyclins. Novel Stable Prostacyclin Analogs as Potent Anti-anginal Agents”, Tetrahedron, vol. 51, No. 32, (1995), pp. 8771-8782.
Barrett Stephen D.
Barta Nancy S.
Endres Gregory W.
Kornilov Andriy M.
Maxey Kirk M.
Cayman Chemical Company, Incorporated
Hays, Esq. Steven W.
Pietragallo Gordon Alfano Bosick & Raspanti, LLP
Puttlitz Karl J
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