Regulation of glucose and insulin levels by GnT-4...

Details Regulation of glucose and insulin levels by GnT-4... Regulation of glucose and insulin levels by GnT-4...

2005-05-27

2011-10-11

Pak, Michael (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

Reexamination Certificate

active

08034556

ABSTRACT:
The invention is based on the discovery that the gylcosylation enzyme GnT-4 increases glyocsylation and the stability of glucose transporter (Glut) family members, e.g., by increasing lectin binding. Modulators of GnT-4 activity can therefore be identified and used for the treatment of diabetes or pre-diabetes. In addition, inhibitors of GnT-4 activity can be used for the treatment of cancer.

REFERENCES:
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Joos et al.; “The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members”;Mol. Membr. Biol.; 18(4):247-256; (2001).
Lowe et al.; “A genetic approach to Mammalian glycan function”;Ann. Rev. Biochem.; 72:643-691 (epub Mar. 2003).
Uldry et al.; “The SLC2 family of facilitated hexose and polyol transporters”;Pflugers Arch—Eur J Physiol; 447:480-489 (Apr. 2004).
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Yoshida et al.; “Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase”;Glycobiology; 9(3):303-310 (1999).
International Search Report and Written Opinion from PCT/US05/18910, dated Mar. 16, 2009 (9 pages).

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