Antibodies that bind ALS specific epitopes and methods of...

Details Antibodies that bind ALS specific epitopes and methods of... Antibodies that bind ALS specific epitopes and methods of...

2010-06-02

2011-12-13

Spector, Lorraine (Department: 1649)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds antigen or epitope whose amino acid sequence is...

C424S001110, C424S130100, C424S184100, C424S185100, C436S543000, C436S544000, C530S387100

Reexamination Certificate

active

08075891

ABSTRACT:
The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent is used to detect protein with target epitope that was inaccessible during contact with the blocking agent. The invention also relates to novel amyotrophic lateral sclerosis-specific epitopes and their uses to make antibodies, and to the novel antibodies and uses thereof.

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