Homogeneous immunoassays for multiple allergens

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is particulate and the particles are of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100, C435S007920, C435S007940, C436S518000, C436S164000, C436S172000

Reexamination Certificate

active

08034632

ABSTRACT:
A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.

REFERENCES:
patent: 4228237 (1980-10-01), Hevey et al.
patent: 4279617 (1981-07-01), Masson et al.
patent: 4459360 (1984-07-01), Marinkovich
patent: 4520110 (1985-05-01), Stryer et al.
patent: 4743541 (1988-05-01), Higgins et al.
patent: 5028545 (1991-07-01), Soini
patent: 5082768 (1992-01-01), Burd et al.
patent: 5362655 (1994-11-01), Schenk et al.
patent: 5478926 (1995-12-01), Nishimura et al.
patent: 5494830 (1996-02-01), Hubscher
patent: 5512659 (1996-04-01), Ullman et al.
patent: 5656207 (1997-08-01), Woodhead et al.
patent: 5846703 (1998-12-01), Devlin et al.
patent: 5866321 (1999-02-01), Matsue et al.
patent: 5972630 (1999-10-01), Cromer et al.
patent: 5981180 (1999-11-01), Chandler et al.
patent: 6054303 (2000-04-01), Davalian et al.
patent: 6087188 (2000-07-01), Johansen et al.
patent: 6159748 (2000-12-01), Hechinger
patent: 6184042 (2001-02-01), Neumann et al.
patent: 6218134 (2001-04-01), Yamauchi et al.
patent: 6245513 (2001-06-01), Lane et al.
patent: 6264619 (2001-07-01), Ferguson
patent: 6268222 (2001-07-01), Chandler et al.
patent: 6274325 (2001-08-01), Deger et al.
patent: 6406667 (2002-06-01), Singh et al.
patent: 6449562 (2002-09-01), Chandler et al.
patent: 6524793 (2003-02-01), Chandler et al.
patent: 6645732 (2003-11-01), Faatz et al.
patent: 6689317 (2004-02-01), Rees
patent: 6939720 (2005-09-01), Chandler et al.
patent: 6979567 (2005-12-01), Herron et al.
patent: 7465540 (2008-12-01), Jacobson et al.
patent: 7491553 (2009-02-01), Brown et al.
patent: 7674632 (2010-03-01), Connelly et al.
patent: 7892853 (2011-02-01), Brown et al.
patent: 2002/0004199 (2002-01-01), Hechinger
patent: 2002/0045195 (2002-04-01), Hubscher et al.
patent: 2002/0055176 (2002-05-01), Ray
patent: 2002/0119497 (2002-08-01), Wild et al.
patent: 2003/0054356 (2003-03-01), Jacobson et al.
patent: 2003/0096433 (2003-05-01), Meyer-Almes
patent: 2005/0101031 (2005-05-01), Hiller et al.
patent: 2005/0191647 (2005-09-01), Meyer-Almes
patent: 2006/0246506 (2006-11-01), Pulli et al.
patent: 2009/0137060 (2009-05-01), Lund-Johansen
patent: 0585369 (1999-04-01), None
patent: 0 556 745 (1993-12-01), None
patent: 0 700 514 (2001-11-01), None
patent: 1 195 606 (2002-04-01), None
patent: 2 251 722 (2006-05-01), None
patent: 2459384 (2009-10-01), None
patent: 1235349 (1992-06-01), None
patent: 1026678 (2006-01-01), None
patent: 504798 (1997-04-01), None
patent: WO 97/14028 (1997-04-01), None
patent: WO 99/36564 (1999-07-01), None
patent: WO 00/50172 (2000-08-01), None
patent: WO 03/050539 (2003-06-01), None
patent: WO 2004/046733 (2004-06-01), None
patent: WO 2007/008084 (2007-01-01), None
patent: WO 2007/067680 (2007-06-01), None
patent: WO 2009/048530 (2009-04-01), None
Barbarakis, M.S., et al., Enhancement of the Emission Intensity of Fluorophore-Labeled Avidin by Biotin and Biotin Derivatives. Evaluation of Different Fluorophores for Improved Sensitivity,Talanta, 40(7), pp. 1139-1145.
Bishop, J.E., et al., A Flow Cytometric Immunoassay for beta2-microglobulin in Whole Blood,Journal of Immunological Methods, 210(1), Dec. 15, 1997, pp. 79-87.
Carpenter, A.B., Enzyme-Linked Immunoassays, Chapter 2,Manual of Clinical Laboratory Immunology, 4thEdition, 1992, Rose et al. eds., American Society for Microbiology, Washington D.C., pp. 2-6.
Carson, R.T., et al., Simultaneous Quantitation of 15 Cytokines Using a Multiplexed Flow Cytometric Assay,Journal of Immunological Methods, Jul. 30, 1999, 227(1-2), pp. 41-52.
Dafforn, A., et al., Miniaturization of the Luminescent Oxygen Channeling Immunoassay (Loci(Tm)) for use in Multiplex Array Formats and Other Biochips,Clinical Chemistry, Sep. 2000, 46(9), pp. 1495-1497.
Derer, M.M., et al., Application of the Dot Immunobinding Assay to Allergy Diagnosis,Journal of Allergy and Clinical Immunology, 74(1), Jul. 1984, pp. 85-92.
Diamandis, et al., Immunoassay, Academic Press, Chapter 11, The Avidin-Biotin System, 1996, pp. 237-267.
Fulton, R.J., et al., Advanced Multiplexed Analysis with the FlowMetrix™ System,Clinical Chemistry, vol. 43, No. 9, 1997, pp. 1749-1756.
Fulwyler, M.J., et al., Flow Microsphere Immunoassay for the Quantitative and Simultaneous Detection of Multiple Soluble Analytes,Methods in Cell Biology, 1990, 33, pp. 613-629.
Haugland, R.P., et al., Preparation of Avidin Conjugates, Chapter 18, Immunochemical Protocols, 2ndEdition, 1998, J.D. Pound ed. Humana Press Inc., Totowa, N.J., pp. 185-196.
Hlavacek, W.S., et al., Quantifying Aggregation of IgE-FcεRI by Multivalent Antigen,Biophysical Journal, vol. 76, May 1999, pp. 2421-2431.
Johansson, S.G.O., et al., in Vitro Assays Allergy, vol. 6, 1988, pp. 93-139.
Luminex, Allergy Testing: Rapid Economical, Multi-Analyte,Luminex Technical Bulletin, 2 pages, Rev. HI109, Jun. 13, 2003.
Luminex, The Luminex LabMap System,Luminex Technical Bulletin, 3 pages, Rev. AL010, Jun. 13, 2003.
Nakamura, A.B., et al., Fluorescence Immunoassays, Chapter 3,Manual of Clinical Laboratory Immunology, 4thEdition, 1992, N.R. Rose et al. eds. American Society for Microbiology, Washington D.C., pp. 7-15.
Olivieri, V., et al., Capture Assay for Specific IgE: An Improved Quantitative Method,Journal of Immunological Methods, 157(1-2), Jan. 4, 1993, pp. 65-72.
Park, M.K, et al., A Latex Bead-Based Flow Cytometric Immunoassay Capable of Simultaneous Typing of MultiplePneumococcal Serotypes(Multibead Assay), Clinical and Diagnostic Laboratory Immunology, May 2000, 7(3), pp. 486-489.
Schulz, A. et al., Detection of Target Molecules on the Single Molecule Level Using Confocal Fluorescence Microscopy in Combination with Microelectophoresis, Conference: Trends in Optics and Photonics, Laser Application to Chemical and Environmental Analysis, Santa Fe, NM, Feb. 11-13, 2000, pp. xiii+213.
Swartzman, E.E., et al., A Homogeneous and Multiplexed Immunoassay for High-Throughput Screening Using Fluorometric Microvolume Assay Technology,Analytical Biochemistry, 271(2), Jul. 1, 1999, pp. 143-151.
Ullman, E.F., Homogeneous Immunoassays: Historical Perspective and Future Promise,Journal of Chemical Education, 76(6), 1999, p. 781.
Wild, et al., The Immunoassay Handbook, Signal Generation and Detection Systems, M. Stockton Press, New York, 1994, pp. 54, 63-82.
Xu, J.X., et al., A Method, Distribution-Analyzing Latex Immunoassay (DALIA), to Measure Specific Immunoglobulin G Against Mite and Wheat Allergen in Human Sera,Allergy, May 1994, 49(5), pp. 323-329.
Anonymous, FluoroTable: Common Fluorophores, 6 pages, 2001 [online] URL: http://web.archive.org/web/20011203181756/http://info.med.yale.edu/genetics/ward/tavi/FISHdyes2.tml.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Homogeneous immunoassays for multiple allergens does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Homogeneous immunoassays for multiple allergens, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Homogeneous immunoassays for multiple allergens will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4256644

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.