Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-07-07
2011-11-22
Chandrakumar, Nizal (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
08063217
ABSTRACT:
A process for preparation of Methyl-(+)-(S)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester or salts thereof [clopidogrel or salts thereof of Formula (I)] having higher chiral purity and products thereof is provided. A process for purification of the compound prepared is also provided to enhance its efficacy by enhancing its optical rotation and chiral purity. In Formula (I), R is selected from a group comprising alkyl, alkoxy, hydroxy, amine etc., and R1is selected from the group comprising C1-4alkyl, C1-4alkoxy, hydroxy, nitro & halogen. The particular salt of interest of the present invention is the hydrogen sulfate of compound of the Formula (I), wherein R and R1are —OCH3and chloro-group at position 2 respectively.
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USP monograph 27NF22, IInd Supplement, effective from Aug. 1, 2004.
European Search Report: EP 06 83 2291.
Dalvi Rajiv Ramchandra
Patil Pravin Chaitram
Pawar Prashant Pandurang
Poojari Krishna Anand
Srivastava Anita Ranjan
Chandrakumar Nizal
Ladas & Parry LLP
RPG Life Sciences Limited
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