Pyrazoloquinolone derivative and use thereof

Details Pyrazoloquinolone derivative and use thereof Pyrazoloquinolone derivative and use thereof

2005-02-18

2010-11-30

Solola, Taofiq A (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S082000

Reexamination Certificate

active

07842701

ABSTRACT:
The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula:wherein R1is an aryl group which may be substituted, or an aromatic heterocyclic group which may be substituted; R2is a hydrogen atom, an amino group which may be substituted, a hydroxy group which may be substituted, or a thiol group which may be substituted; R3, R4, R5and R6, which may be identical or different, are each (1) a hydrogen atom, (2) a nitro group, (3) a cyano group, (4) a halogen atom, (5) a hydrocarbon group which may be substituted, (6) an amino group which may be substituted, (7) a hydroxy group which may be substituted, or (8) a thiol group which may be substituted; and R3and R4, R4and R5, and R5and R6may respectively form a ring together with the adjacent carbon atom, or salt thereof.

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Cecchi et al. “Synthesis and Binding Studies of 1-Arylpyrazolo [4,5-c]- and 2-Arylpyrazolo [4.3-c] Quinolin-4-Ones”.Farmaco. Edizione Scientifica. 1995. vol. 40 pp. 509-516.
International Search Report dated Apr. 5, 2005.

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