Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-05-23
1977-03-15
Milestone, Norma S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260287R, C07D21134
Patent
active
040123960
ABSTRACT:
Cis or trans 2-(1-acyl-3-vinyl-4-piperidine)acetic acid esters and cis or trans 3-(1-acyl-3-vinyl-4-piperidine)propionic acid esters, antipodes and racemates thereof, are prepared, inter alia, from the corresponding cis or trans 2- or 3-[1-acyl-3-(2-chloroethyl)-4-piperidine]acetic or propionic acid esters, respectively. The cis or trans 2- or 3-(1-acyl-3-vinyl-4-piperidine)acetic or propionic acid esters are useful as intermediates for the synthesis of quinine and quinidine and analogs and stereoisomers thereof.
REFERENCES:
patent: 3753992 (1973-08-01), Gutzwiller et al.
Wagner et al., Synthetic Organic Chemistry (1965), pp. 35-36.
Grethe Guenter
Uskokovic Milan Radoje
Hoffmann-La Roche Inc.
Isgro William G.
Leon Bernard S.
Milestone Norma S.
Welt Samuel L.
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