Amelioration of cataracts, macular degeneration and other...

Details Amelioration of cataracts, macular degeneration and other... Amelioration of cataracts, macular degeneration and other...

2004-11-22

2010-11-02

Wang, Shengjun (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C424S400000

Reexamination Certificate

active

07825134

ABSTRACT:
Ophthalmically acceptable compositions used in arresting the development of macular degeneration, retinopathy, glaucoma, eyelid disorders, corneal disease, or uveitis are disclosed. The compositions comprise a pharmaceutically acceptable carrier or diluent and at least one compound having the formula:wherein R1, R2, R3, R4, R5, R6, and R7are as defined herein.

REFERENCES:
patent: 3936456 (1976-02-01), Ramey et al.
patent: 4014335 (1977-03-01), Arnold
patent: 4287175 (1981-09-01), Katz
patent: 4343787 (1982-08-01), Katz
patent: 4404302 (1983-09-01), Gupta et al.
patent: 4615697 (1986-10-01), Robinson
patent: 4691015 (1987-09-01), Behrens et al.
patent: 4804539 (1989-02-01), Guo et al.
patent: 4818537 (1989-04-01), Guo
patent: 4851436 (1989-07-01), Hoffman et al.
patent: 4871742 (1989-10-01), Bonne et al.
patent: 4883658 (1989-11-01), Holly
patent: 4914088 (1990-04-01), Glonek et al.
patent: 4927891 (1990-05-01), Kamath et al.
patent: 4983392 (1991-01-01), Robinson
patent: 5004770 (1991-04-01), Cortolano et al.
patent: 5075104 (1991-12-01), Gressel et al.
patent: 5145893 (1992-09-01), Galbo et al.
patent: 5188928 (1993-02-01), Karino et al.
patent: 5209927 (1993-05-01), Gressel et al.
patent: 5225196 (1993-07-01), Robinson
patent: 5278151 (1994-01-01), Korb et al.
patent: 5294607 (1994-03-01), Glonek et al.
patent: 5399473 (1995-03-01), Shono et al.
patent: 5462946 (1995-10-01), Mitchell et al.
patent: 5466233 (1995-11-01), Weiner et al.
patent: 5475013 (1995-12-01), Talley et al.
patent: 5518732 (1996-05-01), Nigam
patent: 5578586 (1996-11-01), Glonek et al.
patent: 5707643 (1998-01-01), Ogura et al.
patent: 5718922 (1998-02-01), Herrero-Vanrell et al.
patent: 5869079 (1999-02-01), Wong et al.
patent: 5902598 (1999-05-01), Chen et al.
patent: 5981548 (1999-11-01), Paolini et al.
patent: 5981584 (1999-11-01), Egbertson et al.
patent: 6001853 (1999-12-01), Zigler et al.
patent: 6154671 (2000-11-01), Parel et al.
patent: 6251090 (2001-06-01), Avery et al.
patent: 6281192 (2001-08-01), Leahy et al.
patent: 6331313 (2001-12-01), Wong et al.
patent: 6375972 (2002-04-01), Guo et al.
patent: 6410045 (2002-06-01), Schultz et al.
patent: 6429194 (2002-08-01), Leahy et al.
patent: 6433007 (2002-08-01), Garner et al.
patent: 6469057 (2002-10-01), Lai
patent: 2003/0109566 (2003-06-01), Mano et al.
patent: 2004/0002461 (2004-01-01), Matier et al.
patent: 2029402 (1991-05-01), None
patent: 2065796 (1992-10-01), None
patent: 38 01 790 (1989-07-01), None
patent: 40 00 551 (1990-07-01), None
patent: 42 00 192 (1992-07-01), None
patent: 43 27 297 (1994-02-01), None
patent: 44 11 369 (1994-10-01), None
patent: 43 20 444 (1994-12-01), None
patent: 44 24 706 (1995-01-01), None
patent: 44 26 222 (1995-03-01), None
patent: 196 16 185 (1996-10-01), None
patent: 196 18 197 (1997-11-01), None
patent: 198 16 681 (1998-10-01), None
patent: 197 35 255 (1999-02-01), None
patent: 0 138 767 (1988-03-01), None
patent: 0 157 738 (1989-04-01), None
patent: 0 378 054 (1990-07-01), None
patent: 0 490 771 (1992-06-01), None
patent: 0 356 677 (1993-06-01), None
patent: 0 309 400 (1994-03-01), None
patent: 0 352 221 (1994-03-01), None
patent: 0 309 401 (1994-10-01), None
patent: 0 627 428 (1994-12-01), None
patent: 0 638 616 (1995-02-01), None
patent: 0 467 850 (1995-07-01), None
patent: 0 467 848 (1996-01-01), None
patent: 195 30 468 (1997-02-01), None
patent: 0 565 487 (1997-04-01), None
patent: 0 588 763 (1997-12-01), None
patent: 0 508 398 (1998-07-01), None
patent: 0 601 745 (1999-03-01), None
patent: 0 665 294 (1999-05-01), None
patent: 0 644 195 (1999-07-01), None
patent: 0 761 466 (1999-08-01), None
patent: 0 775 684 (1999-08-01), None
patent: 0 641 822 (1999-12-01), None
patent: 0 745 646 (2001-07-01), None
patent: 0 636 610 (2002-03-01), None
patent: 0 943 665 (2003-11-01), None
patent: 0 934 972 (2004-04-01), None
patent: 2 253 411 (1992-09-01), None
patent: 58-99449 (1983-06-01), None
patent: 63-85547 (1988-04-01), None
patent: 3-31342 (1991-02-01), None
patent: 9-52975 (1997-02-01), None
patent: 10-45777 (1998-02-01), None
patent: 10-45778 (1998-02-01), None
patent: 10-219140 (1998-08-01), None
patent: 10-220381 (1998-08-01), None
patent: 2000-327844 (2000-11-01), None
patent: WO 95/17900 (1995-07-01), None
patent: WO 96/15110 (1996-05-01), None
patent: WO 96/37576 (1996-11-01), None
patent: WO 97/39051 (1997-10-01), None
patent: WO 97/39052 (1997-10-01), None
patent: WO 98/28256 (1998-07-01), None
patent: WO 98/47893 (1998-10-01), None
patent: WO 98/50360 (1998-11-01), None
patent: WO 99/05108 (1999-02-01), None
patent: WO 99/33911 (1999-07-01), None
patent: WO 99/43666 (1999-09-01), None
patent: WO 01/17738 (2001-03-01), None
patent: WO 02/34262 (2002-05-01), None
Barbarin, F., et al., “L'effet gem effect: measurement of interfunctional distance by electron paramagnetic resonance,”Nouv. J. Chim.,1980, 4(7), 437-444 (English Abstract).
Carlsson, D.J., et al., “Photostabilization ofpolypropylene by a hindered amine,”J. of Polym. Science: Polym. Letts. Ed.,1981, 19, 549-554.
Carlsson, D.J., et al., “Hindered amines as antioxidants in UV exposed polymers,”Polym. Science Technol.(Plenum), 1984, 26(Polym. Addit.), 35-47.
Chen, K., et al., “Oxidation of hydroxylamines to nitroxide spin labels in living cells,”Biochim. et Biophys. Acta,1988, 970, 270-277.
Chmela, {hacek over (S)}., et al., “The influence of substituents on the photo-stabililizing efficiency of hindered amine stabilizers in polypropylene,”Polym. Degrad.&Stab.,1990, 27, 159-167.
Ciba-Geigy, A.-G., “NOR (Nitrogen-oxygen-R) hindered amine light stabilizers in polymeric microparticles,”Res. Discl.,1991, 323, 155-157 (English abstract).
Dragutan, I., et al., “New amino-nitroxide spin labels,”Bioorg.&Med. Chem.,1996, 4(10), 1577-1583.
Johnson, P.Y., et al., “The reformatsky reaction of ethyl α-bromo esters with Bis(chloromethyl) ether,”J. Org. Chem.,1973, 38(13), 2346-2350.
Klemchuk, P.P., et al., “Stabilization mechanisms of hindered amines,”Polym. Degrad. Stab.,1988, 22, 241-274.
Kokhanov, Y., et al., “Synthesis of some heterocyclic radicals of the iminoxyl class,”Khim. Geterotsikl. Soedin.,1971, 11, 1527-1529.
Kurosaki, T., et al., “Polymers having stable radicals. II. Synthesis of nitroxyl polymers from 4-methacryloyl derivatives of 1-hydroxy-2,2,6,6-tetrarnethylpiperidine,”J. of Polym. Sci.: Polym. Chem. Ed.,1974, 12, 1407-1420.
Litvin, E.F., et al., “Investigation of the stepwise mechanism of the hydrogenation of iminoyxl bi- and polyradicals of platinum and nickel catalysts,”Zh. Org. Kim.,1970, 6(12), 2365-2369.
Nethsinghe, L., et al., “Mechanisms of antioxidant action: complementary chain-breaking mechanisms in the mechanostabilization of rubbers,”Rubber Chem.&Technol.,1984, 57, 918-925.
Ohkatsu, Y., et al., “Inhibition of antoxidation by hindered amine light stabilizers and their derivatives,”Sekiyu Gakkaishi,1994, 37(4), 395-399.
Zahradnickova, A., et al., “Comparison of the stabilization ability of N-substituted hindered-amine light stabilizers in hydrocarbon model compounds and in polymers,”Plasty Kauc.,1987, 24(6), 174-177 (English abstract).
Age-Releated Eye Disease Study Research Group, AREDS Report No. 8,Arch. Ophthalmol.,2001, 119, 1417-1436.
Ahmed, I., et al., “Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea,”J. of Pharm. Sci.,1987, 76(8), 583-586.
Ambati, J., et al., “Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies,”Survey of Ophthalmology,2003, 48(3), 257-293.
Augustin, A.J., et al, “Oxidative reactions in the tear fluid of patients suffering from dry eyes,”Graefe's Arch. Clin. Exp. Ophthalmol.,1995, 233, 694-698.
Berra, A., et al., “Age-related antioxidant capacity of the vitreous and its possible relationship with simultaneous changes in photoreceptors, retinal pigment epithel

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