Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-07-09
2010-11-02
Padmanabhan, Sreeni (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S037000, C514S254010, C514S255010
Reexamination Certificate
active
07825136
ABSTRACT:
The present invention relates to compounds that potentiate the activity of antibacterials. The present invention also relates to compositions useful in treating bacterial infection in mammals, and methods therewith. The present invention also relates to a method of inhibiting bacterial efflux of an antibiotic, thereby increasing the efficacy of the antibiotic.
REFERENCES:
patent: 4853225 (1989-08-01), Wahlig et al.
patent: 5260066 (1993-11-01), Wood et al.
patent: 5543423 (1996-08-01), Zelle et al.
patent: 5620971 (1997-04-01), Armistead et al.
patent: 5989832 (1999-11-01), Trias et al.
patent: 6436980 (2002-08-01), Leger et al.
patent: 6982091 (2006-01-01), Pauletti et al.
patent: 7189740 (2007-03-01), Zeldis
patent: WO 96/36630 (1996-11-01), None
patent: WO 97/36869 (1997-10-01), None
RD269008A, Sep. 1986, Anonymous.
W. N. Konings and G. J. Poelarends, “Bacterial Multidrug Resistance Mediated by a Homologue of the Human Multidrug Transporter P-glycoprotein”,IUBMB Life, 53: 213-218 (2002).
H. W. Van Veen, et al., “Multidrug Resistance Mediated by a Bacterial Homolog of the Human Multidrug Transporter MDR1”Proc. Natl. Acad. Sci. USA, 93: 10668-10672 (1996).
Database Medline ′Online! US National Library of Medicine (NLM), Bethesda, MD, US; Database Accession No. NLM15504837; XP002304037; S. Mullin et al., “Inhibition of Antibiotic Efflux in Bacteria by the Novel Multidrug Resistance Inhibitors Biricodar (VX-710) and Timcodar (VX-853)”,Antimicrobial Agents and Chemotherapy, 48:4171-4176 (2004). (abstract only).
On Line Medical Dictionary, ′Online! May 6, 1997; Retrieved from the Internet URL:http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=actinomycin+d>, retrieved on Nov. 11, 2004; XP002304031.
DiVerdi Michael J.
Padmanabhan Sreeni
Soroush Layla
Vertex Pharmaceuticals Incorporated
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