Mass spectrometer

Details Mass spectrometer Mass spectrometer

1995-08-07

1999-03-02

Anderson, Bruce

Radiant energy

Ionic separation or analysis

With sample supply means

B01D 5944, H01J 4900

Patent

active

058774955

ABSTRACT:
A mass spectrometer comprising a capillary electrophoresis region for separating a solution containing molecules of sample by capillary electrophoresis in a capillary, a nebulization region for nebulizing the solution containing molecules of the sample under an atmospheric pressure from the end of the capillary and forming liquid droplets of the solution containing the molecules of the sample, a vaporization region for vaporizing the liquid droplets under an atmospheric pressure to form gaseous molecules of the sample, a chemical ionization region for forming ions relevant to the molecules of the sample under the atmospheric pressure or the reduced pressure by a chemical reaction between the ions attributable to the gaseous molecules present in the atmosphere and the gaseous molecules of the sample, and a vacuum region having a sample aperture for introducing the ions formed by the chemical ionization means and incorporating a mass analysis region for mass analysis of ions introduced from the sample aperture. The mass spectrometer is combined with the capillary electrophoresis apparatus and is particularly suitable to formation and mass analysis of ions relevant to the neutral molecules of the sample.

REFERENCES:
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patent: 4888482 (1989-12-01), Kato
patent: 4994165 (1991-02-01), Lee et al.
patent: 5051583 (1991-09-01), Mimura et al.
patent: 5170052 (1992-12-01), Kato
patent: 5349186 (1994-09-01), Ikonomou et al.
R. Smith et al., "Improved Electrospray Ionization Interface for Capillary Zone Electrophoresis-Mass Spectrometry", Analytical Chemistry, vol. 60, No. 18, Sep. 15, 1988, pp. 1948-1952.
J. Wahl et al., "Use of small-diameter capillaries for increasing peptide and protein detection sensitivity in capillary electrophoresis-mass spectrometry", Electrophoresis, vol 14, 1993, pp. 448-457. No Month.

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