Transdermal pharmaceutical composition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai

Reexamination Certificate

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Details

C424S400000

Reexamination Certificate

active

07728042

ABSTRACT:
The invention relates to a liquid crystal gel containing polyoxyethylene-glyceryl-trioleate, propylene-glycol, isopropyl myristate and a hyaluronic acid salt or complex for use in the manufacture of transdermal pharmaceutical compositions and healing cosmetics. The invention also relates to transdermal pharmaceutical composition consists of an estrogen and a progestin component as well as a liquid crystal gel containing polyoxyethylene-glyceryl-trioleate, propylene-glycol, isopropyl myristate and a hyaluronic acid salt or complex. The invention can be applied for transdermal hormone replacement therapy and for other transdermal depending on the active principles included.

REFERENCES:
patent: 5326566 (1994-07-01), Parab
patent: 5523093 (1996-06-01), Della Valle et al.
patent: 5616568 (1997-04-01), Pouyani et al.
patent: 5985850 (1999-11-01), Falk et al.
patent: 6069135 (2000-05-01), Falk et al.
patent: 2004/0192620 (2004-09-01), Bunschoten et al.
Brynhildsen et al. Low dose transdermal estradiol
onethisterone acetate treatment over 2 years does not cause endometrial proliferation in postmenopausal women. Menopause.9(2):137-144, Mar. 2002.
Liquid Crystals and Their Applications in Drug Delivery (American Cyanamid Corporation), 1989.

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