Methods for measuring glycan levels of proteins

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100

Reexamination Certificate

active

07838634

ABSTRACT:
The invention includes a high-through-put method of screening for a biomarker indicative of a disease, including the identification of a glycan alteration in a protein of a diseased patient. Further, the invention includes methods utilizing a microarray to measure the glycan level of a protein.

REFERENCES:
patent: 4389392 (1983-06-01), Adachi
patent: 5329028 (1994-07-01), Ashkenazi et al.
patent: 2002/0137104 (2002-09-01), Cosma
patent: 2002/0164824 (2002-11-01), Xiao et al.
patent: 2003/0153014 (2003-08-01), Shen et al.
patent: 2004/0023306 (2004-02-01), Aebersold et al.
patent: 2004/0063624 (2004-04-01), Kage et al.
patent: 0237106 (2002-05-01), None
patent: 03060522 (2003-07-01), None
patent: WO 03087821 (2003-10-01), None
Keusch et al., Clin. Chim. Acta, 1996, 252: 147-158.
Routh et al., J. Neuroscience Methods, 1997, 71:163-168.
Jung et al., Analyst, 2008, 133:697-701.
Taussig et al., Targets, 2003, 2(4): 169-176.
Parker, N. et al. A new enzyme-linked lectin/mucin antibody sandwich assay (CAM 17.1/WGA) assessed in combination with CA 19-9 and peanut lectin binding assay for the diagnosis of pancreatic cancer.Cancer70, 1062-8 (1992).
Blixt, O. et al, Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.Proc Natl Acad Sci U S A101, 17033-17038 (2004).
Haab, B.B., et al. Protein microarrays for highly parallel detection and quantification of specific proteins and antibodies in complex solutions.Genome Biol264, 33-45 (2004).
Kuno, A. et al. Evanescent-field fluorescence-assisted lectin microarray: a new strategy for glycan profiling.Nat Methods2, 851-6 (2005).
Brian B. Haab, et al., “839.4 Antibody microarray analysis of blood serum from cancer patients,” Experimental Biology 2003: Meeting Abstracts, FASEB Journal, p. 1, (Apr. 4, 2003).
Heping Zhou, et al., “Two-color, rolling-circle amplification on antibody microarrays for sensitive, multiplexed serum-protein measurements,” Genome Biology, Article R28, Open Access, vol. 5 ( No. 4), pp. 1-12, (Mar. 30, 2004).
Sudeepa Bhattacharyya, et al., “Diagnosis of Pancreatic Cancer Using Serum Proteomic Profiling,” Neoplasia, vol. 6 (No. 5), p. 674-686, (2004).
Birte Schulenberg, et al., “Mapping glycosylation changes related to cancer using the Multiplexed Proteomics technology: a protein differential display approach,” Journal of Chromatography B 793, Elsevier p. 127-139, (2003).
Darren Hamelinck, et al., “Optimized Normalization for Antibody Microarrays and Application to Serum-Proten Profiling,” Molecular & Cellular Proteomics 4.6, The American Society for Biochemistry and Molecular Biology, p. 773-784, (Mar. 25, 2005).
Jeremy C. Miller, et al., “Antibody microarray profiling of human prostate cancer sera: Antibody screening and identification of potential biomarkers,” Proteomics, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, p. 56-63, (2003).
Chen S et al., Antibody-lectin microarrays reveal altered glycosylation on secreted proteins in pancreatic cancer patients. Proceeding of the Annual Association for Cancer Research 47:337-338 (Apr. 2006).
Haab B et al., RCA-Enhanced Protein Detection Arrays. Methods in Molecular Biology 328: 15-29 (2006).
Rosenfeld R et al., U-c Fingerprint: Glycoprotein Analysis Based on A Lectin Array. Glycobiology 13 (No. 11): 845 (Nov. 2003).
PCT/US2006013557, European Search Report, May 9, 2008.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for measuring glycan levels of proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for measuring glycan levels of proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for measuring glycan levels of proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4250088

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.