Process for preparing cephalosporins and intermediates

Details Process for preparing cephalosporins and intermediates Process for preparing cephalosporins and intermediates

1975-06-12

1977-03-15

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50118, C07D50120

Patent

active

040123812

ABSTRACT:
A process is disclosed for preparing derivatives of 7-amino-cephalosporanic acid and 7-amino-desacetoxycephalosporanic acid of structure: starting from a 3-acylamino-2.beta.-thiohydrazoazetidinone of structure: ##STR1## wherein the compound (II') is reacted with a phosphorous halide in the presence of a tertiary amine, the corresponding imino chloride is reacted with a lower aliphatic alcohol, the iminoether so formed is hydrolyzed with water in an acid medium, and the resultant 3-amino-2.beta.-thiohydrazoazetidinone of structure: ##STR2## is reacted in a suitable solvent and at a temperature between -100.degree. and +120.degree. C with a compound selected from the class consisting of inorganic basic or weakly acid oxides and inorganic and organic bases, to finally give the desired compound (V) which is isolated and purified in known manner.
2.beta.-thiohydrazoazetidinones are also disclosed as intermediates.

REFERENCES:
patent: 3905965 (1975-09-01), Martel et al.

Affiliated with

Also associated with

Rating

Process for preparing cephalosporins and intermediates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing cephalosporins and intermediates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing cephalosporins and intermediates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-424970