Block copolymer micelle composition having an enhanced...

Details Block copolymer micelle composition having an enhanced... Block copolymer micelle composition having an enhanced...

2003-05-30

2010-06-29

Hartley, Michael G (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C516S009000

Reexamination Certificate

active

07744919

ABSTRACT:
A micelle drug composition having an enhanced drug-loading capacity and improved sustained-release characteristics comprising an amphiphilic block copolymer including at least one hydrophilic blocks and at least one hydrophobic blocks. The block copolymer comprises functional groups selected from the group consisting of carboxyl, amine, hydroxyl, amide, thiol and sulfonic acid groups, in the hydrophobic block chain of the copolymer, and the average number of the functional groups range from 1.1 to 30.

REFERENCES:
patent: 5702717 (1997-12-01), Cha et al.
Cammas et al., 1993, Macromolecules, 26, pp. 4681-4684.
Jaeyoung Lee, et al., Incorporation and release behavior of hydrophobic drug . . . ; Journal of Controlled Release 94 (2004) 323-335.

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