Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-02-25
2010-11-23
Whiteman, Brian (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07838659
ABSTRACT:
Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.
REFERENCES:
patent: 6277621 (2001-08-01), Horsburgh et al.
patent: 2004/0077565 (2004-04-01), Pavco et al.
patent: 2005/0096282 (2005-05-01), Lewin et al.
patent: WO 00/66780 (2000-11-01), None
Bloom David C.
Lewin Alfred S.
Liu Jia
Schultz Gregory S.
Tuli Sonal Sanjeev
Beusse Wolter Sanks Mora & Maire
University of Florida Research Foundation Inc.
Van Dyke Timothy H.
Whiteman Brian
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