Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-06-28
2010-06-15
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S184000
Reexamination Certificate
active
07737144
ABSTRACT:
The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diones, pharmaceutically acceptable salts thereof and physiologically functional derivatives.The invention therefore relates to compounds of the formula I,in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are suitable for use as antidiabetics, for example.
REFERENCES:
patent: 5190923 (1993-03-01), Vincent et al.
patent: 6221633 (2001-04-01), Ertl
patent: 6221897 (2001-04-01), Frick et al.
patent: 6245744 (2001-06-01), Frick et al.
patent: 6376509 (2002-04-01), Bakshi et al.
patent: 6380230 (2002-04-01), Brodin et al.
patent: 6399640 (2002-06-01), Sahoo et al.
patent: 6469024 (2002-10-01), Li et al.
patent: 6624185 (2003-09-01), Glombik
patent: 6635653 (2003-10-01), Goehring et al.
patent: 6908926 (2005-06-01), Dorwald et al.
patent: 2039883 (1980-08-01), None
patent: WO 97/26265 (1997-07-01), None
patent: WO 97/41097 (1997-11-01), None
patent: WO 98/08871 (1998-03-01), None
patent: WO 99/03861 (1999-01-01), None
patent: WO 00/40569 (2000-07-01), None
patent: WO 00/64876 (2000-11-01), None
patent: WO 00/66585 (2000-11-01), None
patent: WO 00/71549 (2000-11-01), None
patent: WO 01/09111 (2001-02-01), None
patent: WO 01/83451 (2001-11-01), None
patent: WO 02/20525 (2002-03-01), None
Asakawa A. et al., Cocaine-Amphetamine-Regulated Transcript Influences Energy Metabolism, Anxiety and Gastic Emptying in Mice, Hormone and Metabolic Research, (2001) vol. 33, No. 9, pp. 554-558.
Brown et al, Aza Analogs of Pteridine. III. 3-Amino- from 3-alkoxy-pyrimido(5,4-e)-as-triazin-5-ones prepared by cyclization of 3-ethoxy-1,2,4-triazines or other means, Australian Journal of Chemistry, vol. 27(8), 1974; pp. 1781-1790.
Lee Daniel W et al., Leptin agonists as a potential approach to the treatment of obesity, Drugs of the Future, 2001, vol. 26(9), pp. 873-881.
Lioa, T. et. al., Synthesis of 1-Demethyltoxoflavin (8-Demethytfervenulin)1, Journal of Organic Chemistry, vol. 31, (1965) pp. 900-902.
N. K. Tonks et al., Characterization of the Major Protein-tyrosine-phosphatases of Human Placenta, Journal of Biological Chemistry, vol. 263, No. 14, May 15, 1988, pp. 6731-6737.
Okada H. et al., Synthesis and Antitumor Activities of Prodrugs of Benzoylphenylureas, Chem. Pharm. Bull., (1994), vol. 42, No. 1, pp. 57-61.
P. Tyle, Iontophoretic Devices for Drug Delivery, Pharmaceutical Research, vol. 3, No. 6, 1986.
P.A. Lanzetta et al., An Improved Assay for Nanomole Amounts of Inorganic Phosphate, Analytical Biochemistry, vol. 100, 1979, pp. 95-97.
Ramachandran et al, Protein Tyrosine Phosphatase 1B: A Novel Target for Type 2 Diabetes and Obesity, Curr. Top. Med. Chem., vol. 3(7), 1003; pp. 749-757.
Salvador Javier et al., Perspectives in the therapeutic use of leptin, Expert Opinion on Pharmacotherapy 2001, 2(10), 1615-1622.
T. R. Burke et al., Small Molecule Interactions with Protein-Tyrosine Phosphatase PTP1B and Their Use in Inhibitor Design, Biochemistry, vol. 35, 1996, pp. 15989-15996.
Temple et al, Pyrimido[5,4-e]-as-Triazines. III. The Preparation and some Reactions of 5-Subsitituted Pyrimido[5,4-e]-as-Triazines, J. Org. Chem., vol. 34(7), 1969. pp. 2102-2106.
W. Cromlish et al., Selective Inhibition of Cyclooxygenase-1 and -2 Using Intact Insect Cell Assays, Biochemical Pharmacology, vol. 52, 1996, pp. 1777-1785.
Yoneda et al, Convenient Synthesis of Toxoflavins, Toxoflavin 4-oxides, and 1-demethyltoxoflavins, Chemical & Pharmaceutical Bulletin, vol. 23(9), 1975, pp. 2001-2009.
Yoneda, F. et. al. , Antitumor Agent, Patent Abstracts of Japan vol. Jan. 30, 1998.
Yoneda,F. et. al., A Convenient Synthesis of Toxoflavins. Toxoflavin 4-Oxides and 1-Demethylloxoflavins, Chemical and Pharmaceutical Bulletin vol. 23, No. 9 (1975) pp. 2001-2009.
Zunft, H. et al., Carob Pulp Preparation for Treatment of Hypercholesterolemia, Advances in Therapy, 2001, vol. 18(5), pp. 230-236.
Baringhaus Karl-Heinz
Mueller Guenter
Petry Stefan
Tennagels Norbert
Balasubramanian Venkataraman
Kurys Barbara E.
Sanofi-Aventis Deutschland GmbH
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