Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-03-17
2010-06-15
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S484000, C548S507000
Reexamination Certificate
active
07737170
ABSTRACT:
The present invention relates to uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I):in the treatment of affective disorders.
REFERENCES:
patent: 3803143 (1974-04-01), Tanaka et al.
patent: 4018830 (1977-04-01), Christy
patent: 4055665 (1977-10-01), Christy
patent: 4056632 (1977-11-01), Mehta et al.
patent: 4198417 (1980-04-01), Ong et al.
patent: 4241071 (1980-12-01), Martin et al.
patent: 5095039 (1992-03-01), Mehta et al.
patent: 5945425 (1999-08-01), Moormann et al.
patent: 6410736 (2002-06-01), Howard, Jr. et al.
patent: 6436938 (2002-08-01), Howard, Jr. et al.
patent: 6455738 (2002-09-01), Dubac et al.
patent: 6509340 (2003-01-01), Van Amsterdam et al.
patent: 6596741 (2003-07-01), Howard et al.
patent: 6906078 (2005-06-01), Moorman et al.
patent: 7189501 (2007-03-01), Makuta et al.
patent: 7199147 (2007-04-01), Imazaki et al.
patent: 7217732 (2007-05-01), Kozlowski et al.
patent: 7229751 (2007-06-01), Kimura et al.
patent: 7247651 (2007-07-01), Madera et al.
patent: 2002/0173524 (2002-11-01), Collins et al.
patent: 2003/0187023 (2003-10-01), Kubo et al.
patent: 2003/0207894 (2003-11-01), Theodoridis et al.
patent: 2004/0009959 (2004-01-01), Potter et al.
patent: 2004/0014774 (2004-01-01), Myers et al.
patent: 2004/0023010 (2004-02-01), Bulovic et al.
patent: 2004/0039035 (2004-02-01), Collins et al.
patent: 2004/0072844 (2004-04-01), Madera et al.
patent: 2004/0077854 (2004-04-01), Halazy et al.
patent: 2004/0132778 (2004-07-01), Lacadie et al.
patent: 2004/0137389 (2004-07-01), Fukui et al.
patent: 2004/0176426 (2004-09-01), Houze et al.
patent: 2004/0186148 (2004-09-01), Shankar et al.
patent: 2004/0192664 (2004-09-01), Kunz et al.
patent: 2004/0204451 (2004-10-01), Lacadie et al.
patent: 2004/0209936 (2004-10-01), Bratton et al.
patent: 2004/0220237 (2004-11-01), Fu et al.
patent: 2004/0266732 (2004-12-01), Galvez et al.
patent: 2005/0107599 (2005-05-01), Makioka et al.
patent: 2005/0123501 (2005-06-01), Lewis
patent: 2005/0136065 (2005-06-01), Valiante, Jr.
patent: 2005/0152859 (2005-07-01), Dooley et al.
patent: 2005/0153980 (2005-07-01), Schadt et al.
patent: 2005/0159556 (2005-07-01), Lewis et al.
patent: 2005/0189519 (2005-09-01), Gothe et al.
patent: 2005/0206994 (2005-09-01), Kokeguchi et al.
patent: 2005/0228020 (2005-10-01), Miyamoto et al.
patent: 2005/0238992 (2005-10-01), Kodama
patent: 2005/0250794 (2005-11-01), Napper et al.
patent: 2005/0261298 (2005-11-01), Solow-Cordero et al.
patent: 2005/0282861 (2005-12-01), Friary et al.
patent: 2006/0030593 (2006-02-01), Bernotas et al.
patent: 2006/0069203 (2006-03-01), Lewis et al.
patent: 2007/0004923 (2007-01-01), Kobayashi et al.
patent: 2007/0054224 (2007-03-01), Yoneyama et al.
patent: 2007/0054904 (2007-03-01), Knolle et al.
patent: 2007/0060595 (2007-03-01), Yoshizawa et al.
patent: 0 273 199 (1988-07-01), None
patent: 0 396 827 (1990-11-01), None
patent: 0 402 097 (1990-12-01), None
patent: 0 755 923 (1997-01-01), None
patent: 0 814 084 (1997-12-01), None
patent: 0 921 124 (1999-06-01), None
patent: 1 793 272 (2007-06-01), None
patent: WO 93/11106 (1993-06-01), None
patent: WO 93/12080 (1993-06-01), None
patent: WO 94/14770 (1994-07-01), None
patent: WO 97/17325 (1997-05-01), None
patent: WO 97/17352 (1997-05-01), None
patent: WO 97/48698 (1997-12-01), None
patent: WO 98/08817 (1998-03-01), None
patent: WO 00/37456 (2000-06-01), None
patent: WO 00/59878 (2000-10-01), None
patent: WO 00/66537 (2000-11-01), None
patent: WO 01/10842 (2001-02-01), None
patent: WO 01/27068 (2001-04-01), None
patent: WO 01/49677 (2001-07-01), None
patent: WO 01/49678 (2001-07-01), None
patent: WO 01/49679 (2001-07-01), None
patent: WO 02/40024 (2002-05-01), None
patent: WO 02/062766 (2002-08-01), None
patent: WO 02/098857 (2002-12-01), None
patent: WO 03/029232 (2003-04-01), None
patent: WO 03/055873 (2003-07-01), None
patent: WO 03/087086 (2003-10-01), None
patent: WO 2006/006172 (2006-01-01), None
patent: WO 2006/018850 (2006-02-01), None
patent: WO 2006/022405 (2006-03-01), None
patent: WO 2006/038741 (2006-04-01), None
patent: WO 2006/063606 (2006-06-01), None
Depressed Mood [online] retrieved on Dec. 2, 2008; retrieved from the Internet [URL; http://www.healthline.com/adamcontent/depression.
Fibromyalgia [online] retrieved on Dec. 2, 2008; retrieved from the Internet [URL; http://www.nlm.nih.gov/medlineplus/ency/article/000427.htm.
Obsessive-compulsive disorder [online] retrieved on Dec. 2, 2008; retrieved from the Internet [URL; http://www.nlm.nih.gov/medlineplus/ency/article/000929.htm].
Sindelar, K., et al. Potential Antidepressants and Inhibitors of 5-Hydroxy-Tryptamine and Noradrenaline Re-uptake in the Brain: N,N-Dimethyl-(Arylthio)Thenylamines and N,N-Dimethyl-2-(Thienyltio)Benzylamines. Collect. Czech. Chem. Commun. 1991. 56:449-458.
Axford. L., et al. Bicyclo[2.2.1]heptanes as Novel Triple Re-uptake Inhibitors for the Treatment of Depression. Bioorganic & Medicinal Chemistry Letters. 2003. 13:3277-3280.
Emond, P., et al. Substituted Diphenyl Sulfides as Selective Serotonin Transporter Ligands: Synthesis and In Vitro Evaluation. J. Med. Chem. 2002. 45(6):1253-1258.
Hawkins, D.G., et al. Competitive Cyclisation of Singlet and Triplet Nitrenes. Part 7. Reaction Pathways of 2-Azidophenyl Benzothienyl Azides. J. Chem. Soc., Perkin Trans. I. 1979. 3207-3210.
Jackson, A., et al. Electrophilic Substitution in Indoles. Part 16. 1.2 The Formation of Indolobenzothiazines and Indolobenzothiazepines by Intramolecular Cyclisation of (o-Nitrophenylthio)indoles. J. Chem. Res. Miniprint 9, 1988. 2017-2063.
Jilek, J. et al. Potential Antidepressants: 2-(Methoxy- and Hydroxy-Phenylthio)Benzylamines as Selective Inhibitors of 5-Hydroxytryptamine Re-uptake in the Brain. Collect Czech. Chem. Commun. 1989. 54:3294-3338.
Martin, L., et al. Synthesis of Spiro[isobenzofuran-1(3H),4′piperedines] as potential Central Nervous System Agents. 5. Conformationally Mobile Analogues Derived by Furan Ring Opening. J. Med. Chem. 1979. 22(11):1347-1354.
Oya, S., et al. A New Single-Photon Emission Computed Tomography Imaging Agent for Serotonin Transporters: [123I]IDAM, 5-Iodo-2-((2-((dimethylamino)methyl)-phenyl)thio)benzyl Alcohol. J. Med. Chem. 1999. 42(3):333-335.
Oya, S., et al. New PET Imaging Agent for the Serotonin Transporter: [18F]ACF (2-[(2-Amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine). J. Med. Chem. 2002. 45(21):4716-4723.
Ragno, R., et al. Docking and 3-D QSAR Studies on Indolyl Aryl Sulfones. Binding Mode Exploration at the HIV-1 Reverse Transcriptase Non-Nucleoside Binnding Site and Design of Higly Active N-(2-Hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide Derivatives. J. Med. Chem. 2005. 48(1):213-223.
Silvestri, R., et al. Novel Indolyl Aryl Sulfones Active Against HIV-1 Carrying NNRTI Resistance Mutations: Synthesis and SAR Studies. J. Med. Chem. 2003. 46(12):2482-2493.
Sejberg, J. Synth[e]sis of 3- and 2-phenylsulfanyl-1H-indole [thesis] (English Translation). Lyngby (Denmark): Technical University of Denmark; Jan. 21, 2003. 102 pages (Tables 6, 7 and 8 are attached at the end of the document). Available from: Technical University of Denmark, Lyngby, DK; d991811.
Abstract and STN Search Report cited in the Jul. 10, 2008 Office Action in connection with parallel U.S. Appl. No. 11/452,823.
A. Burger, “Isosterism and Bioisosterism in drug design”. Prog. Drug Res. 1991, 37:287-371.
Mitra, et al.; “Thiophenes & Thiapyrans: Part XVII—Thieno-(2:3-b)-thionaphthene & Thionaphtheno-(2:3-b)-thionaphthene”, Journal of Scientific & Industrial Research., 1957, 16B:348-54.
Depressed Mood [online] retrieved on Dec. 2, 2008; retrieved from the Internet [URL; http://www.healthline.com/adamcontent/depresion].
Fibromyalgia [online] retrieved on Dec. 2, 2008; retrieved from the Internet [URL; http://www.nlm.nih.gov/medlineplus/ency/article/000427.htm].
Wong, D.T. “Duloxetine (LY 248686): an inhibitor of Serotonin and noradrenaline uptake and antidepressant drug candidate” Exp. Opin. Invest. Drugs, 1998, 7(10), 1
Juhl Karsten
Kehler Jan
Nørgaard Morten Bang
Sejberg Jimmy
Anderson Rebecca L
Buck Margaret M.
H. Lundbeck A/S
Kalinchak Stephen G.
Young Shawquia
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