Cyclic ketal beta-secretase inhibitors for the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S283400, C514S422000, C514S473000, C548S517000, C549S475000

Reexamination Certificate

active

07816378

ABSTRACT:
The present invention is directed to cyclic ketal compounds of formula (I)which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

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patent: 7115652 (2006-10-01), Yang
patent: 7132568 (2006-11-01), Yang et al.
patent: 7291620 (2007-11-01), Coburn et al.
patent: 2001/0016595 (2001-08-01), Ducharme et al.
patent: 2006/0149092 (2006-07-01), Nantermet et al.
patent: 2006/0293380 (2006-12-01), Nantermet et al.
patent: 2007/0088165 (2007-04-01), Nantermet et al.
patent: 2007/0142634 (2007-06-01), Barrow et al.
patent: WO 2005/051914 (2005-06-01), None
patent: WO 2005/051914 (2005-06-01), None
patent: WO 2005/065195 (2005-07-01), None
patent: WO 2005/065195 (2005-07-01), None
Luethy et. al., “Preparation of substituted pyridines as herbicides”, Hcaplus 2005:564642 abstract, Jun. 30, 2005.

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