Metabotropic glutamate-receptor-potentiating isoindolones

Details Metabotropic glutamate-receptor-potentiating isoindolones Metabotropic glutamate-receptor-potentiating isoindolones

2006-02-15

2010-10-05

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S472000

Reexamination Certificate

active

07807706

ABSTRACT:
Compounds of formula I:wherein R1, R2, R3, R4, R5, R6, R7, R8, R9and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.

REFERENCES:
patent: 3579524 (1971-05-01), Van Dyke et al.
patent: 3993617 (1976-11-01), Schwan
patent: 5175157 (1992-12-01), Psiorz et al.
patent: 5681954 (1997-10-01), Yamamoto et al.
patent: 2003/0212094 (2003-11-01), Yamabe et al.
patent: 2005/0026976 (2005-02-01), Curtin et al.
patent: 2007/0082907 (2007-04-01), Canada et al.
patent: 620 654 (1963-01-01), None
patent: 0 548 934 (1993-06-01), None
patent: WO-99/26927 (1999-06-01), None
patent: WO-2004/024702 (2004-03-01), None
patent: WO-2004/031178 (2004-04-01), None
patent: WO-2005/040157 (2005-05-01), None
patent: WO-2005/074643 (2005-08-01), None
patent: WO-2005/085214 (2005-09-01), None
patent: WO-2005/085216 (2005-09-01), None
patent: WO-2006/020879 (2006-02-01), None
patent: WO-2006/047237 (2006-05-01), None
patent: WO-2006/091496 (2006-08-01), None
Mertz et al., Synthetic Receptors for CG Base Pairs, 2000, Organic Letters, vol. 2, No. 19, 2931-2934.
Vippagunta et al., Crystalline solids, 2001, Advanced Drug Delivery Reviews, 48, pp. 3 and 18.
Barr et al.; Journal of Organometallic Chemistry, vol. 302, No. 1, Mar. 11, 1986, pp. 117-126, XP002383544.
Hoarau C et al: Synthesis, No. 5, 2000, pp. 655-660, XP002383545.
Rys V et al: European Journal of Organic Chemistry, No. 7, Apr. 2003, pp. 1231-1237, XP002383546.
Clayden J et al: Organic Letters, vol. 2, No. 26, 2000, pp. 4229-4232, XP002345295.
Couture A et al: Tetrahedron Letters, vol. 43, No. 12, Mar. 18, 2002, pp. 2207-2210 XP004344002.
Casagrande C et al: IL Farmaco, Edizione Scientifica, vol. 27, No. 6, Jun. 1972, pp. 445-470, XP000 571647.
Bonnefous at al., Bioorganic & Medicinal Chemistry Letters, vol. 15, p. 4354-4358 (2005).
Bonnefous et al. (Merck), poster presented at the 229th National Meeting of the American Chemical Society, San Diego, CA, Mar. 2005; poster, MEDI-37.
Yamamoto Y. et al: Organic and Biomoleculae chemistry, vol. 2, No. 9, May 2004, pp. 1287-1294, XP002357868.
Moreau a at al: Tetrahedron, vol. 60, No. 29, Jul. 12, 2004, pp. 6169-6176 XP002357869.
Hatt H H et al: Journal of the Chemical Society, 1952, pp. 199-205 XP002357871.
Bohme H et al: Die Pharmazie, No. 25, 1970, pp. 283-289, XP002357872.
Bailey DM et al: Journal of Medicinal Chemistry, vol. 14, No. 3, pp. 240-241, XP002357873, 1971.
Mori M et al: Journal of Organic Chemistry, vol. 43, No. 9, Apr. 28, 1978, pp. 1864-1867, XP002357874.
Grigg R et al: Tetrahedron Letters, vol. 44, No. 37, Sep. 8, 2003, pp. 6979-6982, XP004447066.
Norman M H et al.: Journal of Medicinal Chemistry, vol. 39, No. 1, 1996, pp. 149-157, XP000982309.
Zhuang Z-P et al: Journal of Medicinal Chemistry, vol. 41, No. 2, Jan. 15, 1998, pp. 157-166, XP002357875.
Norman M H, et al: Journal of Medicinal Chemistry, vol. 36, No. 22, Oct. 29, 1993, pp. 3417-3423, XP002357876.
Ahn K H et al: Bioorganic & Medicinal Chemistry Letters, vol. 9, No. 10, May 17, 1999, pp. 1379-1384, XP004164896.
Sugimoto H et al: Journal of Medicinal Chemistry, vol. 35, No. 24, 1992, pp. 4542-4548, XP002319779.
Mayer P et al: Journal of Medicinal Chemistry, vol. 43, Sep. 19, 2000, pp. 3653-3664, XP001183987.
Breytenbach J C et al: Bioorganic & Medicinal Chemistry Letters, vol. 10, No. 15, Aug. 7, 2000, pp. 1629-1631, XP004213210.
Anderson P S et al: Journal of Organic Chemistry, vol. 44, No. 9, 1979, pp. 1519-15, XP002981802.
Luzzio F A et al: Tetrahedron Letters, vol. 40, No. 11, Mar. 12, 1999, pp. 2087-2090, XP002357870.

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