Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-06
1999-03-02
Marschel, Ardin H.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 6, 435 911, 436501, 436 94, C07K 100, C12Q 168, G01N 33566, G01N 3300
Patent
active
058772804
ABSTRACT:
Isolated nucleic acids which encode a thermostable protein which binds specifically to bulge loops in a heteroduplex nucleic acid and recombinant vectors comprising nucleic acid which encodes a thermostable protein which binds specifically to bulge loops in a heteroduplex nucleic acid are disclosed. Also disclosed are isolated thermostable proteins which bind specifically to bulge loops in a heteroduplex nucleic acid and host cells comprising a recombinant gene which can express a thermostable protein which binds specifically to bulge loops in a heteroduplex nucleic acid. Further disclosed are a method of reducing DNA misincorporation in an amplification reaction, methods for detecting a nucleic acid which includes a specific sequence, a method for amplifying a nucleic acid comprising a specific sequence, and a method for selecting against a nucleic acid comprising a specific sequence.
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Marschel Ardin H.
Riley Jezia
The Mount Sinai School of Medicine of the City University of New
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