Modified polynucleotides for reducing off-target effects in...

Details Modified polynucleotides for reducing off-target effects in... Modified polynucleotides for reducing off-target effects in...

Filed on

2007-09-19

Date issued

2010-11-16

Examiner

Chong, Kimberly (Department: 1635)

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Carbohydrates or derivatives

Other Related Categories

C536S024310, C536S024100, C514S04400A, C435S006120, C435S325000, C435S375000

Type

Reexamination Certificate

Status

active

Patent number

07834171

Description

ABSTRACT:
Methods and compositions for performing RNA interference with decreased off-target effects are provided. The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2′-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands.

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