Compositions for treating hearing loss and methods of use...

Details Compositions for treating hearing loss and methods of use... Compositions for treating hearing loss and methods of use...

2007-04-04

2010-06-22

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S024300, C536S024330, C514S04400A, C435S006120, C435S091100, C435S325000, C435S375000

Reexamination Certificate

active

07741469

ABSTRACT:
This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of genes encoding proteins involved in deafness caused by dominant negative mechanism of action by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid, short interfering RNA, double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes involved in deafness caused by dominant negative mechanism of action.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5624803 (1997-04-01), Noonberg et al.
patent: 6395713 (2002-05-01), Beigelman et al.
patent: 2005/0182007 (2005-08-01), McSwiggen et al.
patent: WO 93/23569 (1993-11-01), None
patent: WO 94/02595 (1994-02-01), None
patent: WO 96/10390 (1996-04-01), None
patent: WO 96/10391 (1996-04-01), None
patent: WO 96/10392 (1996-04-01), None
patent: WO 96/18736 (1996-06-01), None
Yano et al. Molecular Carcinogenesis, 2001 vol. 31:101-109.
Hammond et al. Nature Reviews, 2001 vol. 2:110-119.
Scanlon, KJ. Current Pharmaceutical Biotechnology, 2004 vol. 5:415-420.
GenBank Accession No. AF281280, published Aug. 2, 2000.
Ambion siRNA target finder (http://www.ambion.com/techlib/misc/siRNA—finder.html, available 2002 to the public, results for GenBank Accession No. AF281280).
Internet Archive WayBackMachine (http://web.archive.org/web/*/http://www.ambion.com/techlib/misc/siRNA—finder.html).
Aldrian-Herrada et al., 1998, Nucleic Acids Res., 26, 4910-4916.
Boado et al., 1998, J. Pharm. Sci., 87, 1308-1315.
Boado, 1995, Adv. Drug Delivery Rev., 15, 73-107.
Chen et al., 1992, Nucleic Acids Res., 20, 4581-9.
Chowrira et al., 1994, J. Biol. Chem., 269, 25856).
Coucke PJ, et al. Hum Mol Genet 1999; 8(7): 1321-8.
Couture et al., 1996, TIG., 12, 510.
Denoyelle, F. et al.Hum. Mol. Genet. 6, 2173-2177. (1997).
Denoyelle, F et al.Nature. 393, 319-320 (1998).
Di, W.L. et al.,Cell Commun. Adhes. 8 415-418 (2001).
Dropulic et al., 1992, J. Virol., 66, 1432-41.
Duckert, L.G. et al..Otolaryngology. 86, 434-446 (1978).
Elbashir, S.M. et al.,EMBO J. 20, 6877-6888 (2001).
Elroy-Stein and Moss, 1990, Proc. Natl. Acad. Sci. USA, 87, 6743-7.
Emerich, DF et al, 1999, Cell Transplant, 8, 47-58.
Estivill, X. et al.Lancet. 351, 394-398 (1998).
Fire A. Trends Genet 1999; 15(9): 358-63.
Frier et al., 1986, Proc. Nat. Acad. Sci. USA 83:9373-9377.
Gao and Huang 1993, Nucleic Acids Res., 21, 2867-72.
Good et al., 1997, Gene Therapy, 4, 45.
Green, G.E. et al.JAMA. 281, 2211-2216 (1999).
Ishiwata et al., Chem. Pharm. Bull. 1995, 43, 1005-1011.
Izant and Weintraub, 1985, Science, 229, 345.
Janecke, A.R. et al.Hum. Genet. 108, 269-270 (2001).
Jero J, et al. Hum Gene Ther 2001; 12(5): 539-48).
Jolliet-Riant and Tillement, 1999, Fundam. Clin. Pharmacol., 13, 16-26.
Kashani-Sabet et al., 1992, Antisense Res. Dev., 2, 3-15.
Kelsell, D.P. et al.Nature387, 80-83 (1997).
Kharkovets T, et al. EMBO J 2006; 25(3): 642-52. Epub Jan. 26, 2006.
Kubisch C, et al. Cell 1999; 96(3): 437-46.
Landegran et al., 1988,Science, 241:1077-1080.
Lasic et al., Science 1995, 267, 1275-1276.
Lasic et al. Chem. Rev. 1995, 95, 2601-2627.
Lee et al., 2002,Nat. Biotech., 20:500-5.
Lieber et al., 1993, Methods Enzymol., 217, 47-66.
Liu et al., J. Biol. Chem. 1995, 42, 24864-24870.
Lisziewicz et al., 1993, Proc. Natl. Acad. Sci. U S. A, 90, 80004.
L'Huillier et al., 1992, EMBO J, 11, 4411-8.
Martinez, J. et al.,Cell110, 563-574 (2002).
Marziano, N.K. et al.,Hum. Mol. Genet. 12, 805-812 (2003).
McGarry and Lindquist, 1986, Proc. Natl. Acad. Sci., USA 83, 399.
McGuirt, W.T. et al.Nat. Genet. 23, 413-419 (1999).
Miyagishi and Taira, 2002, Nature Biotechnology, 19, 497.
Nakazawa et al., 1994,Proc. Natl. Acad. Sci. USA, 91:360-364.
Noonberg et al., 1994, Nucleic Acid Res., 22, 2830.
Ohkawa et al., 1992, Nucleic Acids Symp. Ser., 27, 15-6.
Oku et al., 1995, Biochim. Biophys. Acta, 1238, 86-90.
Ojwang et al., 1992, Proc. Natl. Acad. Sci. USA, 89, 10802-6.
Pardridge et al., 1995, PNAS USA., 92, 5592-5596.
Paul et al., 2002, Nature Biotechnology, 19, 505.
Prieskorn, D.M. & Miller, J.M.Hear. Res. 140, 212-215 (2000).
Richard, G. et al.Hum. Genet. 103, 393-399 (1998).
Rouan, F. et al.,J. Cell Sci. 114, 2105-2113 (2001).
Sarver et al., 1990 Science, 247, 1222-1225.
Scanlon et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 10591-5.
Schroeder et al., Prog Neuropsychopharmacol Biol Psychiatry, 23, 941-949, 1999.
Shepherd, R.K. et al.,Arch. Otolaryngol. Head Neck Surg. 130, 518-523 (2004).
Sullenger & Cech, 1993, Science, 262, 1566.
Taira et al., 1991, Nucleic Acids Res., 19, 5125-30.
Templeton, N.S. et al.Nat. Biotechnol. 15, 647-652 (1997).
Thompson et al., 1995, Nucleic Acids Res., 23, 2259.
Turner et al., 1987, CSH Symp. Quant. Biol. LII pp. 123-133.
Turner et al., 1987, J. Am. Chem. Soc. 109:3783-3785.
Tyler et al., 1999, PNAS USA., 96, 7053-7058.
Tyler et al., 1999, FEBS Lett., 421, 280-284.
van Hauwe P, et al. Am J Med Genet 2000; 93(3): 184-7.
Ventura et al., 1993, Nucleic Acids Res., 21, 3249-55.
Wadhwa, R. et al.,Mutat. Res. 567, 71-84 (2004).
Weerasinghe et al., 1991, J. Virol., 65, 55314.
Yu et al., 1993, Proc. Natl. Acad. Sci. USA, 90, 6340-4.
Zhou et al., 1990, Mol. Cell. Biol., 10, 4529-37.
Applied Biosystems TechNotes 10(4), Sep. 2003.
Elbashir et al., (2001) Nature 411:494-498.
Harborth et al., (2003) Antisense Nucleic Acid Drug Dev. 13:83-106.
Tuschl lab (May 8, 2003) “The siRNA user guide”.
Semizarov et al., (2003) Proc. Natl Acad Sci USA 100:6347-6352.
Jackson et al., (2003) Nat Biotechnol. 21:635-637.
Editors of Nature Cell Biology, (2003) Nat. Cell. Bio. 5:489-490.
Screen-shot, siRNA Target Finder, 2008.
Reynolds et al., (2004) Nat Biotechnol. 22(3):326-30.

Affiliated with

Also associated with

Rating

Compositions for treating hearing loss and methods of use... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions for treating hearing loss and methods of use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions for treating hearing loss and methods of use... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4234242