Dimers of unsymmetrical cyanine dyes

Details Dimers of unsymmetrical cyanine dyes Dimers of unsymmetrical cyanine dyes

1994-01-06

1996-12-10

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 405, 536 231, 546165, C12Q 168, G01N 3352, C07H 2102, C07H 2104

Patent

active

055829775

ABSTRACT:
The invention relates to dimers of unsymmetrical cyanine dyes, typically dimers of benzthiazole or benzoxazole derivatives, that exhibit enhanced fluorescence on binding with DNA or RNA, The dimers generally have the formula: ##STR1## where R.sup.1 and R.sup.2, which may be the same or different, are alkyl groups having 1-6 carbons;

REFERENCES:
patent: 4304908 (1981-12-01), Frishberg et al.
patent: 4883867 (1989-11-01), Lee
Chemical Abstracts vol. 88, No. 6, Abstract No. 38936q.
Brooker, et al., J. Am. Chem. Soc. 64, 199 (1942).
Lee, et al., Thiazole Orange: A New Dye for Reticulocyte Analysis, Cytometry 7, 508 (1986).
Rye, et al., Nucleic Acids Research 19(2), 327 (1990).
Haugland, Molecular Probes Handbook of Fluorescent Probes and Research Chemicals Set 28 (1989).
Griffiths, Colour and Constitution of Organic Molecules, pp. 241 Academic Press (1976).
Ausubel, et al., Short Protocols in Molecular Biology, p. 359, John Wiley & Sons.

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