Function of autophagy genes in cell death

Details Function of autophagy genes in cell death Function of autophagy genes in cell death

2005-05-02

2010-11-23

Aeder, Sean E (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C530S387100

Reexamination Certificate

active

07838645

ABSTRACT:
The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by caspase 8 inhibition and expression of the mammalian genes ATG7 and beclin.

REFERENCES:
patent: 5837837 (1998-11-01), Hunter et al.
patent: WO 03/020767 (2003-03-01), None
Serazin-Leroy (Am J Physiol Endoconol Metab, 2000, 279:E1398-E1405).
Verma et al. (Nature 1997, 389: 239-242).
Amalfitano et al. (Current Gene Therapy 2002, 2: 111-133).
Pandha et al. (Current Opinion in Investigational Drugs 2000; 1 (1): abstract).
McNeish et al (Gene Therapy, 2004, 11:497-503).
Burgess et al. (J. Cell Biol. 111:2129-2138, 1990).
Lazar et al. ( Mol. Cell Biol. 8:1247-1252, 1998).
Christiansen et al (Mol Cancer Ther, 2004, 3:1493-1501).
Topp et al (Journal of Controlled Release, 1998, 53:15-23).
Pandha et al. (Current Opinion in Investigational Drugs 2000; 1 (1): 122-134).
McCormick (Nature Reviews, 2001, 1:130-141).
Berry et al (Autophagy, Apr. 2008, 1;4(3):359-360).
Berry et al (Cell, Dec. 2007, 14;131(6): 1137-1148).
A. Degterev, M. Boyce, J. Yuan,Oncogene22, 8543-67 (2003).
D. W. Nicholson, N. A. Thornberry,Science299, 214-5 (2003).
A. Strasser, L. O'Connor, V. M. Dixit,Annual Review of Biochemistry69, 217-45 (2000).
M. Leist, M. Jaattela,Nature Reviews Molecular Cell Biology2, 589-98 (2001).
F.K. Chan, J. Shisler, J.G. Bixby, M. Felices, L. Zheng, M. Appel, J. Orenstein, B. Moss, M.J. Lenardo,J Biol Chem. 278, 51613-21 (2003).
N. Holler et al.,Nature Immunology1, 489-95 (2000).
Y. Ohsumi,Nature Reviews Molecular Cell Biology2, 211-6 (2001).
D. J. Klionsky, S. D. Emr,Science290, 1717-21 (2000).
E. H. Baehrecke,Nature Reviews Molecular Cell Biology3, 779-87 (2002).
W. Fiers, R. Beyaert, W. Declercq, P. Vandenabeele,Oncogene18, 7719-30 (1999).
S.M. Gorski, et al.Current Biology13, 358-63 (2003).
C. Y. Lee et al.,Current Biology13, 350-7 (2003).
L. Jia et al.,British Journal of Haematology98, 673-85 (1997).
I. Tanida, N. Mizushima, M. Kiyooka, M. Ohsumi, T. Ueno, Y. Ohsumi, E. Kominami,Mol Biol Cell. 10, 1367-79 (1999).
J. Kim, V.M. Dalton, K.P. Eggerton, S.V. Scott, D.J. Klionsky,Mol Biol Cell. 10, 1337-51 (1999).
X. H. Lianget et al.,Journal of Virology72, 8586-96 (1998).
X. H. Liang et al.,Nature402, 672-6 (1999).
Z. Yue, S. Jin, C. Yang, A. J. Levine, N. Heintz,Proceedings of the National Academy of Sciences of the United States of America100, 15077-82 (2003).
X. Qu et al.,J Clin Invest. 112, 1809-20 (2003).
A. Devin, Y. Lin, Z.G. Liu,EMBO Rep. 4, 623-7 (2003).
RW. Oppenheim, RA Flavell, S. Vinsant , et al.,J. Neutosci. 21, 4752-60 (2001).
H. J. Chun et al,Nature419, 395-9 (2002).28.
Y. Lin, A. Devin, Y. Rodriguez, Z. G. Liu,Genes&Development13, 2514-26 (1999).
K.R. Mills, M. Reginato, J. Debnath, B. Queenan, J.S. Brugge,Proceedings of the National Academy of Sciences of the United States of America101, 3438-43 (2003).
M. Li et al.,Science288, 335-9 (2000).
J. Yuan, M. Lipinski, A. Degterev,Neuron40, 401-13 (2003).
B. Levine, DJ. Klionsky,Dev. Cell6, 463-477 (2004).
M. Tsukada, Y. Ohsumi,FEBS Letters333, 169-74 (1993).
M. Thumm, R. Egner, B. Koch, M. Schlumpherger, M. Straub, et al.FEBS Letters349, 275-280 (1994).
M. Chautan, G. Chazal, F. Cecconi, P. Gruss, et al.,Curr. Biol., 9, 967-70 (1990).
T. M. Harding, Ka Morano, SV Scott, et al.,J. Cell Biol. 131, 591-602 (1995).
DJ. Klionsky, JM Cregg, WAJ Dunn, SD Ernt, et al.Dev Cell5, 539-45 (2003).

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