Tripeptide prodrug compounds

Details Tripeptide prodrug compounds Tripeptide prodrug compounds

2007-03-27

2010-10-19

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S018700, C530S331000

Reexamination Certificate

active

07816317

ABSTRACT:
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.

REFERENCES:
patent: 4376765 (1983-03-01), Trouet et al.
patent: 5648457 (1997-07-01), Takei et al.
patent: 6897034 (2005-05-01), Bebbington et al.
patent: 7304032 (2007-12-01), Bebbington et al.
patent: 7425541 (2008-09-01), Dubois et al.
patent: 2002/0142955 (2002-10-01), Dubois et al.
patent: WO-96/05863 (1996-02-01), None
Pozsgay et al. Substrate and Inhibitor Studies of Thermolysin-Like Neutral Metalloendopeptidsase From Kidney Membrane Fractions. Comparison With Bacterial Thermolysin. Biochemistry, vol. 25, pp. 1292-1299. 1986.
Canadian Office Action for Application No. 2,411,545, dated Dec. 1, 2009.

Affiliated with

Also associated with

Rating

Tripeptide prodrug compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tripeptide prodrug compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tripeptide prodrug compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4227819