Protein inhibitor of Ran activity and methods of use thereof

Details Protein inhibitor of Ran activity and methods of use thereof Protein inhibitor of Ran activity and methods of use thereof

2007-01-18

2010-06-22

Noakes, Suzanne M. (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C530S324000

Reexamination Certificate

active

07741022

ABSTRACT:
The invention provides a method of inhibiting Ran protein activity in at least one eukaryotic cell or cell-free extract, the method comprising exposing an amino acid sequence comprising at least a portion of EMCV or TMEV leader protein, wherein the amino acid sequence comprises SEQ. ID NO: 14 or SEQ. ID NO: 15, to at least one cell in an amount effective to inhibit Ran activity in the targeted cell and evaluating Ran protein activity in the cell.

REFERENCES:
Porter et al. Proceedings from the National Academies of Science, Aug. 15, 2006;103(33):12417-22. Epub Aug. 3, 2006.
Lidsky, P.V.; Nucleocytoplasmic Traffic Disorder Induced by Cardioviruses; Journal of Virology, 2006; p. 2705-2717.
Dvorak, C.M.T.; Leader Protein of Encephalomyocarditis Virus Binds Zinc, Is Phosphorylated during Viral Infection, and Affects the Efficiency of Genome Translation; Virology, 2001; p. 261-271.
Porter, F.W.; A Picornavirus Protein Interacts with Ran-GTPase and Disrupts Nucleocytoplasmic Transport; PNAS, 2006; p. 12417-12422.
Delhaye, S.; The Leader Protein of Theiler's Virus Interferes with Nucleocytoplasmic Trafficking of Cellular Proteins; Journal of Virology, 2004; p. 4357-4362.
Belov, G.A.; Bidirectional Increase in Permeability of Nuclear Envelope upon Polivirus Infection and Accompanying Alterations of Nuclear Pores; Journal of Virology, 2004; p. 10166-10177.

Affiliated with

Also associated with

Rating

Protein inhibitor of Ran activity and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein inhibitor of Ran activity and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein inhibitor of Ran activity and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4226638