Epothilone derivatives

Details Epothilone derivatives Epothilone derivatives

2005-03-15

2010-11-02

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S203000, C548S204000

Reexamination Certificate

active

07825141

ABSTRACT:
Epothilone derivatives of Formula (I) and their use as a pharmaceutical.

REFERENCES:
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Nicolaou et al., “Designed epothilones: Combinatorial synthesis, tubulin assembly properties, and cytotoxic action against taxol, resistant tumor cells,” Angewandte Chemie, International Edition, Verlag Chemie, Weinheim, DE, vol. 36(19), pp. 2097-2103 (1997).
Nicolaou et al., “Chemical synthesis and biological evaluation of novel epothilone B and trans-12, 13-cyclopropyl epothilone B analogues,” Tetrahedron, vol. 58(32), pp. 6413-6432 (2002).
Altmann et al., “Synthesis and Biological Evaluation of Highly Potent Analogues of Epothilones B and D,” Bioorganic and Medicinal Chemistry Letters 10(24):2765-2768 (2000).
Nicolaou et al., “Chemical Synthesis and Biological Evaluation of cis- and trans-12, 13-Cyclopropyl and 12, 13-Cyclobutyl Epothilones and Related Pyridine Side Chain Analogues,” J. Am. Chem. Soc. 123(38):9313-9323 (2001).
Nicolaou et al., “The Olefin Metathesis Approach to Epothilone A and Its Analogues,” J. Am. Chem. Soc. 119 (34):7960-7973 (1997).

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