Polynucleotide barcoding

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07829278

ABSTRACT:
A polynucleotide is barcoded using a method whereby an isolated, individual polynucleotide is immobilized on a solid phase and stretched, targets are labeled using target-specific hybridization probes, and an individual label of an unamplified probe at each of the labeled targets is optically detected. The order of the labels is determined to form a barcode representation of the polynucleotide wherein the targets and their relative positions are represented.

REFERENCES:
patent: 6013431 (2000-01-01), Soderlund et al.
Oana et al., Biochem Biophys Res Commun, 1999, 265: 140-143.
Nilsson et al., Science, 1994, 265: 2085-2088.
Yildiz et al., Science, Jun. 2003, 300: 2061-2065.

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