Peptides for activation and inhibition of δPKC

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S300000

Reexamination Certificate

active

07745388

ABSTRACT:
Peptides able to inhibit or activate the translocation or function of δPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for δPKC-selective agonists and antagonists.

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Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Sailen Barik, Department of Biochemistry and Molecular Biology, University of Southern Alabama, Mobile, Alabama, US Mar. 19, 1998.
Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Derek Miles Yellon, Hatter Institute for Cardiovascular Studies, Department of Academic and Clincial Cardiology, University of College Hospital and Medical School, London, UK Jun. 25, 1998.
Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Derek Miles Yellon, Hatter Institute for Cardiovascular Studies, Department of Academic and Clincial Cardiology, University of College Hospital and Medical School, London, UK Oct. 14, 1998.
Email to Dr. Dr. Derek Miles Yellon, Hatter Institute for Cardiovascular Studies, Department of Academic and Clincial Cardiology, University of College Hospital and Medical School, London, UK Oct. 14, 1998.
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Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Fiorenzo Battaini, Institute of Pharmacological Sciences, University of Milano Milano, IT, Oct. 15, 1998.
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Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Ashwani Malhotra, Cardiovascular Research Institute, New York Medical College, Valhalla, New York, US, Oct. 16, 1998.
Ashwanu Malhotra, List of peptides provided for expermiental use sent to Dr. Ashwani Malhotra, Cardiovascular Research Institute, New York Medical College, Valhalla, New York, US, Oct. 16, 1998.
Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Naoaki Saito, Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, JP, Oct. 15, 1998.
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Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Mohamed Boutjdir, Department of Cardiology, VA Medical Center, Brooklyn, New York, US, Aug. 14, 1998.
Che-Hong Chen, List of peptides provided for expermiental use sent to Drs. Rik Derynck and Huizhou Fan, Department of Growth and Development, University of California, San Francisco, San Francisco, California, US, Oct. 27, 1998.
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Daria Mochly-Rosen, Email regarding request for peptides for expermiental use from Drs. Rik Derynck and Huizhou Fan, Department of Growth and Development, University of California, San Francisco, San Francisco, California, US, Sep. 11, 1998.
Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Marsha Rosner, Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, Illinois, US, Nov. 17, 1998.
Daria Mochly-Rosen, Email regarding request for peptides for expermiental use from Dr. Marsha Rosner, Oct. 27, 1998.
Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. John Hayslett, Yale School of Medicine, New Haven, Conneticut, US, Dec. 14, 1998.
John Hayslett, Letter to Dr. Mochly-Rosen requesting peptides, Oct. 28, 1998.
Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Guang S. Liu, Department of Physiology, University of South Alabama, Mobile, Alabama, US, Nov. 23, 1998.
Daria Mochly-Rosen, signed Material Transfer Agreement with Dr. Steven Pelech, Department of Medicine, University of British Columbia, Vancouver, B.C., CA, Feb. 10, 1999.
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Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Chaya Brodie, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel, Mar. 11, 1999.
Email traffic between Drs. Mochly-Rosen and Brodie regarding peptides.
Daria Mochly-Rosen, Material Transfer Agreement to Dr. Chaya Brodie, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel, Mar. 11, 1999.
Che-Hong Chen, List of peptides provided for expermiental use sent to Dr. Mireia Gomez-Angelats, National Institute of Environmental Health Sciences, RTP, NC, US, Jul. 13, 1999.

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