Bicyclic nitroimidazole-substituted phenyl oxazolidinones

Details Bicyclic nitroimidazole-substituted phenyl oxazolidinones Bicyclic nitroimidazole-substituted phenyl oxazolidinones

2009-03-25

2010-02-23

Habte, Kahsay T (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S091000, C540S552000, C548S218000, C514S211100, C514S375000

Reexamination Certificate

active

07666864

ABSTRACT:
The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such asMycobacterium tuberculosis.

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