Processes for the preparations of cefepime

Details Processes for the preparations of cefepime Processes for the preparations of cefepime

2004-04-15

2010-12-07

Berch, Mark L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07847093

ABSTRACT:
This invention provides processes for preparing cefepime, including crystalline intermediates of Formula V.

REFERENCES:
patent: 4266049 (1981-05-01), Bonjouklian
patent: 4336253 (1982-06-01), Lunn et al.
patent: 4406889 (1983-09-01), Hartmann et al.
patent: 4489072 (1984-12-01), Imaizumi et al.
patent: 4692516 (1987-09-01), Kirrstetter et al.
patent: 4767852 (1988-08-01), Ascher
patent: 4959495 (1990-09-01), Curran et al.
patent: 4960766 (1990-10-01), Takaya et al.
patent: 5026843 (1991-06-01), Riccardo et al.
patent: 5109131 (1992-04-01), Naito et al.
patent: 5574154 (1996-11-01), Abu-Nasrieh
patent: 5574155 (1996-11-01), Danklmaier et al.
patent: 5583216 (1996-12-01), Ochiai et al.
patent: 6384215 (2002-05-01), Deshpande
patent: 6458949 (2002-10-01), Handa et al.
patent: 6919449 (2005-07-01), Deshpande et al.
patent: 7339055 (2008-03-01), Deshpande et al.
patent: 7479556 (2009-01-01), Manca et al.
patent: 2002/0156272 (2002-10-01), Totschnig et al.
patent: 2005/0043531 (2005-02-01), Handa et al.
patent: 2005/0080070 (2005-04-01), Deshpande et al.
patent: 2006/0058281 (2006-03-01), Senthilkumar et al.
patent: 2006/0094872 (2006-05-01), Senthilkumar et al.
patent: 2006/0100424 (2006-05-01), Manca et al.
patent: 0030294 (1981-06-01), None
patent: 0074268 (1983-03-01), None
patent: 0 137 440 (1985-04-01), None
patent: 0335297 (1989-10-01), None
patent: 0492277 (1992-07-01), None
patent: 0 531 981 (1993-03-01), None
patent: 0842937 (1996-11-01), None
patent: WO 00/63214 (2000-10-01), None
patent: WO 2006067803 (2006-06-01), None
Database Casreact XP002297198; Database Accession No. 140:111151 RX(1) and Gong et al., Hongguo Yaowu Huaxue Zazhi, vol. 12, No. 6, pp. 350-351, 362 (2002).
Walker, “New Cephalosporin Acylating Agents Derived from SYN-2(2-Aminothiazol-4-YL)-2-Methoxyimino Acetic Acid. Application to the Synthesis of Cefepime Sulfate”, Tetrahedron Letters, vol. 31, No. 45, pp. 6481-6484 (1990).
Donald G. Walker, et al., “Use of Bistrimethylsilylated Intermediates in the Preparation of Semisynthetic 7-Amino-3-substituted-cephems. Expedient Syntheses of a new 3-[(1-Methyl-1-pyrrolidinio) methyl] cephalosporin,” 1988 American Chemical Society, J. Org. Chem, 1988, 53, pp. 983-991.
J. E. Swigor, et al.,“Synthesis of 7-[alpha-(2-aminothiazol-4-yl)-alpha-(z)-methoximinoacetamido]-3-(1-[14C] methylpyrrolidinio)-methyl-3-cephem-4-carboxylate Sulfate,” Journal of Labelled Compounds and Radiopharmaceuticals—vol. XXIV, No. 1, pp. 15-22.
Tomoyasu Ishikawa, et. al., “Synthesis and Antibacterial Activity of 7Beta-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-alkoxyiminoacetamido]-3-(substituted limidazo[1,2-b]pyridazinium-1-yl)methyl-3-cephem-4-carboxylates and Related Compounds,” The Journal of Antibiotics, vol. 53, No. 10, Oct. 2000, pp. 1071-1085.
Mitsuo Numata, et al., “New Cephalosporins with 7-Acyl Groups Derived from Beta-Katoacids,” The Journal of Antibiotics, Dec. 1978, pp. 1252-1261.
Mitsuo Numata, et al., “A New Cephalosporin. SCE-963: 7-[2-(2-Aminothiazo-4-YL)-acetamido]-3-[[[1-(2-Dimethylaminothyl)-1H-Tetrazol-5-YL]-Thio]Methyl]Ceph-3-EM-4-Carboxylic Acid,” The Journal of Antibiotics, Dec. 1978, pp. 1262-1271.
Hideaki Yamanaka, et al., “Studies of Beta-Lactam Antibiotics IX. Synthesis and Biological Activity of a New Orally Active Cephalosporin, Cefixime (FK027),” The Journal of Antibiotics, Dec. 1985, pp. 1738-1751.

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