Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2009-01-22
2010-12-07
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C436S518000
Reexamination Certificate
active
07846680
ABSTRACT:
Methods are disclosed for assaying at the light microscopic level for the presence or absence of nucleolar channel systems (NCSs) in an endometrial tissue sample, as are methods for determining whether or not a postovulatory human endometrium is in a state that is receptive for implantation of a human embryo, where the presence of NCSs indicates that the endometrium is in a state that is receptive for implantation of an embryo and the absence of NCSs indicates that the endometrium is not in a state that is receptive for implantation of the embryo, and methods for determining the effectiveness of a contraceptive in a woman, comprising assaying an endometrial tissue sample for the presence or absence of NCSs.
REFERENCES:
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Dubowy R L et al., entitled “Improved endometrial assessment using cyclin E and p27,” Fertility and Sterility, vol. 80, No. 1, Jul. 2003, 146-156.
Guffanti E et al., entitled “Nucleolar Channel Systems of Human Endometrial Epithelial Cells Mark the Preimplantation Window,” abstract of poster presented at the 2nd SGI International Summit on Reproductive Medicine, Nov. 8-10, 2007 in Valencia, Spain.
Guffanti E et al., entitled “Nuclear pore complex proteins mark the implantation window in human endometrium,” Journal of Cell Science, 121, 2008, 2037-2045.
Kittur N D, entitled “Studies on the Biogenesis of Two Nucleolar Entities: H/ACA RNPs and the Nucleolar Channel System,” Ph.D. Thesis submitted to Albert Einstein College of Medicine of Yeshiva University, Jan. 2007, available to public May 2007, pp. i-170.
Kittur N, entitled “The Nucleolar Channel System of Human Endometrium Is Related to Endoplasmic Reticulum and R-Rings,” Molecular Biology of the Cell, vol. 18, 2296-2304, Jun. 2007.
Albert Einstein College of Medicine of Yeshiva University
Amster Rothstein & Ebenstein LLP
Cheu Jacob
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