Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-11-18
2010-12-14
Ewoldt, G. R (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07851164
ABSTRACT:
The invention relates to protein ZnT-8 which is specifically expressed in the pancreatic beta cells in islets of Langerhans, to a polynucleotide encoding said protein which is involved in the maturation and exocytosis of insulin, and to the applications thereof, for example, for sorting and studying beta cells and for screening medicine acting on diabetes and hyperinsulinism.
REFERENCES:
patent: 01/42789 (2001-06-01), None
patent: 02/24733 (2002-03-01), None
Melton D. et al.: “Homo sapienscDNA clone IMAGE: 5779491 5′ similar to TR:Q62941 zinc transporter ZNT-2; mRNA sequence” Database EMBL ′Online! ik02a02.y1 Human insulinoma, May 9, 2002. XP002246606.
Tomita T: “New markers for pancreatic islets and islet cell tumors” Pathology International 2002 Japan, vol. 52, No. 7, pp. 425-432, 2002. XP002246605.
Favier Alain
Seve Michel
Commissariat a l''Energie Atomique
Ewoldt G. R
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
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