Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-10-20
1991-04-16
Doll, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 4, 514866, 530303, 530304, A61K 3726, C07K 740, C07K 742
Patent
active
050082418
ABSTRACT:
Insulin analogs characterized by amino acid residue at A21 other than Asn, with a resulting improvement in stability of insulin solutions at acid pH levels. Some insulin analogs may also have amino acid residue changes elsewhere so that these insulin analogs exhibit at least about one charge more than human insulin at a pH value of 7, with preferred substitutions being made for the glutamic acid residues at A4, A17, B13, B21 and/or a basic amino acid residue being substituted at B27. Also contemplated is optional blocking the C-terminal carboxyl group of the B-chain with an amido or ester residue.
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Langkjaer Liselotte
Markussen Jan
Norris Kjeld
Chan Christina
Doll John
Fidelman Morris
Novo Nordisk A S
Wolffe Franklin D.
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