Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2004-04-14
2010-10-12
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S326000, C544S334000, C544S335000, C514S256000, C514S269000
Reexamination Certificate
active
07812160
ABSTRACT:
The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
REFERENCES:
patent: 42 39 440 (1993-06-01), None
patent: 1 170 594 (2002-01-01), None
patent: 1 413 306 (2004-04-01), None
patent: 1471057 (2004-10-01), None
patent: 1356834 (1974-06-01), None
patent: 2 262 096 (1992-03-01), None
patent: WO 01/83485 (2001-11-01), None
patent: WO 03/066047 (2003-08-01), None
patent: WO 2004/058164 (2004-07-01), None
patent: WO 2004/096777 (2004-11-01), None
patent: WO 2008/156780 (2008-12-01), None
patent: WO 2008/156781 (2008-12-01), None
Wolft Manfred E. “Burger's Medicinal Chemistry, 5ed, Part 1”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutices, 3ed.”, Marcel Dekker, New York. 1996, pp. 451 and 596.
Pettipher R., British Journal of Pharmacology,153, S191-S199, 2008.
Hata et al., Pharmacology & Therapeutics 103, 147-166, 2004.
International Search Report of International Application No. PCT/EP2004/003910 having a Publication No. WO 04/096777.
Sugimoto, H., et al, An Orally Bioavailable Small Molecule Antagonist of CRTH2, Ramatroban (Bay U3405), Inhibits Prostaglandin D2-Induced Eosinophil Migration In Vitro, J. Pharmacology & Experimental Therapeutics, Am. Soc. for Pharmacology and, U.S., vol. 305, No. 1, pp. 347-352 (2003).
Ulven, T., et al, Novel Selective Orally Active CRTH2 Antagonists for Allergic Inflammation Developed from In Silico Derived Hits, J. Med. Chem., 49, pp. 6638-6641 (2006).
Ordukhanyan, A. A., et al, Khimiko-Farmatsevticheskii Zhurnal, 13(9): 36-40 (1979) (English abstract provided).
Ly, T. W., et al, Small-Molecule CRTH2 Antagonists for the Treatment of Allergic Inflammation: An Overview, Expert Opin. Investig. Drugs, 14(7): 769-773 (2005).
Yamamoto et al., “The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo [1,2-c] pyrimidin-5-ylamino]-nicotinamide dihydrochloride (Bay 61-3606) blocks antigen-induced airway inflammation in rodents,”J Pharmacol Exp Therapeutics306(3):1174-1181 (2003).
U.S. Appl. No. 12/665,705, filed Dec. 18, 2009, Tai Wei Ly.
U.S. Appl. No. 12/665,706, filed Dec. 18, 2009, Tai Wei Ly et al.
Bacon Kevin
Koriyama Yuji
Ly Tai-wei
Manabe Yoshihisa
Sato Hiroki
Actimis Pharmaceuticals, Inc.
Balasubramanian Venkataraman
Jones Day
LandOfFree
Pyrimidine derivatives useful for the treatment of diseases... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrimidine derivatives useful for the treatment of diseases..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidine derivatives useful for the treatment of diseases... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4210744