Aminopyrimidines useful as kinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S317000

Reexamination Certificate

active

07820685

ABSTRACT:
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

REFERENCES:
patent: 3133081 (1964-05-01), Lafferty et al.
patent: 3755322 (1973-08-01), Winter et al.
patent: 3935183 (1976-01-01), Baron et al.
patent: 3998951 (1976-12-01), Harnish et al.
patent: 4051252 (1977-09-01), Mayer et al.
patent: 4493726 (1985-01-01), Burdeska et al.
patent: 4540698 (1985-09-01), Ishikawa et al.
patent: 4711951 (1987-12-01), Axen et al.
patent: 5124441 (1992-06-01), Carlsson et al.
patent: 5710158 (1998-01-01), Myers et al.
patent: 5916908 (1999-06-01), Giese et al.
patent: 5972946 (1999-10-01), Murata et al.
patent: 6093716 (2000-07-01), Davis et al.
patent: 6184226 (2001-02-01), Chakravarty et al.
patent: 6200977 (2001-03-01), Cushing et al.
patent: 6277989 (2001-08-01), Chakravarty et al.
patent: 6495582 (2002-12-01), Hale et al.
patent: 6528509 (2003-03-01), Hale et al.
patent: 6528513 (2003-03-01), Cushing et al.
patent: 6558657 (2003-05-01), Mandeville, III et al.
patent: 6562971 (2003-05-01), Frauenkron et al.
patent: 6569499 (2003-05-01), Grammatica et al.
patent: 6579983 (2003-06-01), Batchelor et al.
patent: 6589958 (2003-07-01), Frietze
patent: 6593326 (2003-07-01), Bradbury et al.
patent: 6610677 (2003-08-01), Davies et al.
patent: 6613776 (2003-09-01), Knegtel et al.
patent: 6638926 (2003-10-01), Davies et al.
patent: 6641579 (2003-11-01), Bernardi et al.
patent: 6642227 (2003-11-01), Cao et al.
patent: 6653300 (2003-11-01), Bebbington et al.
patent: 6653301 (2003-11-01), Bebbington et al.
patent: 6656939 (2003-12-01), Bebbington et al.
patent: 6660731 (2003-12-01), Bebbington et al.
patent: 6664247 (2003-12-01), Bebbington et al.
patent: 6689778 (2004-02-01), Bemis et al.
patent: 6696452 (2004-02-01), Davies et al.
patent: 6716851 (2004-04-01), Cai et al.
patent: 6727251 (2004-04-01), Bebbington et al.
patent: 6743791 (2004-06-01), Cao et al.
patent: 6825190 (2004-11-01), Moon et al.
patent: 6838464 (2005-01-01), Pease et al.
patent: 6841579 (2005-01-01), Plowman et al.
patent: 6846928 (2005-01-01), Bebbington et al.
patent: 6884804 (2005-04-01), Choon-Moon
patent: 6919338 (2005-07-01), Mortlock et al.
patent: 6949544 (2005-09-01), Bethiel et al.
patent: 6989385 (2006-01-01), Bebbington et al.
patent: 7008948 (2006-03-01), Bebbington et al.
patent: 7084159 (2006-08-01), Cao et al.
patent: 7087603 (2006-08-01), Bebbington et al.
patent: 7091343 (2006-08-01), Bebbington et al.
patent: 7098330 (2006-08-01), Bebbington et al.
patent: 7115739 (2006-10-01), Bebbington et al.
patent: 7179826 (2007-02-01), Bebbington et al.
patent: 7253187 (2007-08-01), Cao et al.
patent: 7304061 (2007-12-01), Hale et al.
patent: 2002/0052386 (2002-05-01), Armistead et al.
patent: 2002/0065270 (2002-05-01), Moriarty et al.
patent: 2003/0064982 (2003-04-01), Davies et al.
patent: 2003/0069248 (2003-04-01), Chakravarty et al.
patent: 2003/0096813 (2003-05-01), Cao et al.
patent: 2003/0105090 (2003-06-01), Bebbington et al.
patent: 2003/0199526 (2003-10-01), Choquette et al.
patent: 2003/0207873 (2003-11-01), Harrington
patent: 2004/0009981 (2004-01-01), Bebbington et al.
patent: 2004/0097531 (2004-05-01), Ledeboer et al.
patent: 2004/0157893 (2004-08-01), Bebbington et al.
patent: 2004/0167141 (2004-08-01), Bebbington et al.
patent: 2004/0214814 (2004-10-01), Bebbington et al.
patent: 2005/0038023 (2005-02-01), Bebbington et al.
patent: 2005/0234059 (2005-10-01), Hale et al.
patent: 2006/0270660 (2006-11-01), Charrier et al.
patent: 0019811 (1980-12-01), None
patent: 0136976 (1985-04-01), None
patent: 0302312 (1989-02-01), None
patent: 2 052 487 (1981-01-01), None
patent: 06-065237 (1994-03-01), None
patent: 10-130150 (1998-05-01), None
patent: 2000-026421 (2000-01-01), None
patent: WO 93/22681 (1993-11-01), None
patent: WO 95/09851 (1995-04-01), None
patent: WO 95/15758 (1995-06-01), None
patent: WO 96/14843 (1996-05-01), None
patent: WO 97/09325 (1997-03-01), None
patent: WO 97/19065 (1997-05-01), None
patent: WO 98/02434 (1998-01-01), None
patent: WO 98/11095 (1998-03-01), None
patent: WO 98/14450 (1998-04-01), None
patent: WO 98/16502 (1998-04-01), None
patent: WO 98/38171 (1998-09-01), None
patent: WO 99/18781 (1999-04-01), None
patent: WO 99/41253 (1999-08-01), None
patent: WO 99/47154 (1999-09-01), None
patent: WO 99/62518 (1999-12-01), None
patent: WO 99/65897 (1999-12-01), None
patent: WO 00/12497 (2000-03-01), None
patent: WO 00/21955 (2000-04-01), None
patent: WO 00/38675 (2000-07-01), None
patent: WO 00/39101 (2000-07-01), None
patent: WO 00/42029 (2000-07-01), None
patent: WO 00/59509 (2000-10-01), None
patent: WO 00/78757 (2000-12-01), None
patent: WO 01/12621 (2001-02-01), None
patent: WO 01/25220 (2001-04-01), None
patent: WO 01/39777 (2001-06-01), None
patent: WO 01/40215 (2001-06-01), None
patent: WO 01/44242 (2001-06-01), None
patent: WO 01/47879 (2001-07-01), None
patent: WO 01/47897 (2001-07-01), None
patent: WO 01/60816 (2001-08-01), None
patent: WO 01/64655 (2001-09-01), None
patent: WO 01/74768 (2001-10-01), None
patent: WO 01/79198 (2001-10-01), None
patent: WO 02/08244 (2002-01-01), None
patent: WO 02/18346 (2002-03-01), None
patent: WO 02/22601 (2002-03-01), None
patent: WO 02/22602 (2002-03-01), None
patent: WO 02/22603 (2002-03-01), None
patent: WO 02/22604 (2002-03-01), None
patent: WO 02/22605 (2002-03-01), None
patent: WO 02/22606 (2002-03-01), None
patent: WO 02/22607 (2002-03-01), None
patent: WO 02/22608 (2002-03-01), None
patent: WO 02/24667 (2002-03-01), None
patent: WO 02/47690 (2002-06-01), None
patent: WO 02/50065 (2002-06-01), None
patent: WO 02/50066 (2002-06-01), None
patent: WO 02/057259 (2002-07-01), None
patent: WO 02/059111 (2002-08-01), None
patent: WO 02/059112 (2002-08-01), None
patent: WO 02/062789 (2002-08-01), None
patent: WO 02/066461 (2002-08-01), None
patent: WO 02/068415 (2002-09-01), None
patent: WO 02/079197 (2002-10-01), None
patent: WO 03/026664 (2003-04-01), None
patent: WO 2004/000833 (2003-12-01), None
patent: WO 2004/013140 (2004-02-01), None
patent: WO 2007/041358 (2007-04-01), None
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20th Edition, vol. 1, pp. 1004-1010, 1996.
Rogers et al., PubMed Abstract (J Cell Biol. 157(2):219-29) Apr. 2002.
Tanaka et al., PubMed Abstract (Cell. 108(3):317-29) Feb. 2000.
Agarwal, N. et al., “Suitably Functionalized Pyrimidines as Potential Antimycotic Agents”, Bioorg. Med. Chem. Lett., 10, 8, 703-706 (2000).
Ali, N.M. et al, “Palladium-Catalyzed Cross Coupling Reactions of Arylboronic Acids with Pi-Deficient Heteroaryl Chlorides” Tetrahedron, 48 (37), 8117-8126 (1992).
Alonso, M. et al., “GSK-3 Inhibitors: Discoveries and Developments”, Current Medicinal Chemistry, 11, 755-763 (2004).
Anderson, Neil G. “Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase.” Nature, 343, 651-653 (1990).
Anonymous, “Vertex Inhibitors of Aurora-2, glycogen synthase kinase-3 and Src Kinase”, Expert Opin. Ther. Patents, 14(3): 439-443 (2004).
Baig, G.U. et al., “Triazines and Related Products. Part 28′ Conversion of 3-Aryl-l-(2-cyanopheny1) triazenes into 3-Arylquinazolin-4(3H)-ones with Formamide” J. Chem. Soc. Perkin Trans. I, 2765-2766 (1984).
Baig, Ghouse Unissa et al. “Triazines and related products. Part 27. Thermolysis of 4-anilino-1,2,3-benzotriazines,”J. Chem., Soc., Perkin Trans. 1(5): 999-1003 (1984).
Banker, G.S. et al., “Modern Pharmaceutics”, 3rd ed., Marcel Dekker, New York 1996, pp. 451 & 596.
Biagi, G. et al., “Synthesis of 4,6-Disubstituted and 4,5,6-Trisubstituted-2-Phenyl-pyrimidines and their Affinity Towards A1 Adenosine Receptors”, IL Farmaco., 52(1), 61-65 (1997).
Biscardi, J.S. et

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