Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1990-12-07
1992-05-26
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 31195
Patent
active
051168731
ABSTRACT:
Oral or parenteral administration of thyroid hormone T.sub.4 (from 0.5 to 2 .mu.g/100 g of body weight) stimulates, normalizes dopaminergic innervation in the corpus striatum (striate body), and restores neurochemical compensation following denervation of selective brain areas, thereby increasing neuronal plasticity.
REFERENCES:
Schiaffino et al., 1980, Chem. Abs. 93(15):146947f, Myosin Polymorphism, Cellular Heterogeneity and Elasticity of Cardiac Muscle.
The Journal of Clinical Psychiatry, vol. 47, No. 2, 1986, p. 100; C. A. Peabody et al.: "Progressive dementia associated with thyroid disease" *The whole article*.
Arzneimittel-Forschung, vol. 31, No. 3, 1981, pp. 437-441; G. Schneider et al.: "Untersuchungen zur symptomatischen Pharmakotherapie eines moglichen Thermodells fur die Chorea Huntington" *Abstract p.441, par. 4.
Reprod. Nutr. Develop. vol. 22, No. 1B, 1982, pp. 201-208; C. Legrand et al.: "Influence of altered thyroid and nutritional states on early histoganosis of the rat cerehellar cortex with special reference to synaptogenesis" *Summary; discussion p. 206*.
Biological Reviews, vol. 54, No. 2, 1979, pp. 155-197; J. A. Kiernan: "Hypotheses concerned with axonal regeneration in the mammalian nervous system"*p. 163, par. 3-p. 164, par. 3; p. 185, summary paragraph 5*.
W. Forth et al.: "Pharmakologie und Toxikologie" 4th edition, 1983 pp. 392-393, Bibliographisches Institut AG, Zurich, CH *p. 392, last paragraph--p. 393, paragraph 1*.
Development Brain Research, vol. 36, 1987, pp. 109-120; M. Hayashi et al.: "An interaction between thyroid hormone and nerve growth factor in the regulation of choline acetyltransferase activity in neuronal cultures, derived from the septal-diagonal band region of the embryonic rat brain" *Abstract; pp. 109-110, paragraph: Introduction: p. 117, par. 2: Discussion; p. 118, par. 5, 6.
Genazzani Enrico
Gorio Alfredo
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