Methods for assessing CDK5 activation and function

Details Methods for assessing CDK5 activation and function Methods for assessing CDK5 activation and function

2007-05-25

2010-10-05

Stucker, Jeffrey (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007200, C435S007800, C435S007920

Reexamination Certificate

active

07807381

ABSTRACT:
As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or activate Cdk5. Of particular relevance are interactions that stimulate calpain cleavage of p35 into p25, which binds Cdk5 in pathologic states. Assays to identify modulators of these interactions are provided.

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