Tumor necrosis factor-gamma

Details Tumor necrosis factor-gamma Tumor necrosis factor-gamma

2007-08-10

2010-10-26

Romeo, David S (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387100, C530S387300, C530S388100, C530S389100, C435S007100, C435S326000

Reexamination Certificate

active

07820798

ABSTRACT:
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

REFERENCES:
patent: 4002531 (1977-01-01), Royer
patent: 4179337 (1979-12-01), Davis et al.
patent: 4433092 (1984-02-01), Nemeth
patent: 4444887 (1984-04-01), Hoffman
patent: 4474893 (1984-10-01), Reading
patent: 4631211 (1986-12-01), Houghten
patent: 4676980 (1987-06-01), Segal et al.
patent: 4708781 (1987-11-01), Poorten
patent: 4714681 (1987-12-01), Reading
patent: 4716111 (1987-12-01), Osband et al.
patent: 4741900 (1988-05-01), Alvarez et al.
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4873191 (1989-10-01), Wagner et al.
patent: 4925648 (1990-05-01), Hansen et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 4994560 (1991-02-01), Kruper et al.
patent: 5112946 (1992-05-01), Maione
patent: 5122464 (1992-06-01), Wilson et al.
patent: 5194392 (1993-03-01), Geysen
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5225539 (1993-07-01), Winter
patent: 5258498 (1993-11-01), Huston et al.
patent: 5274119 (1993-12-01), Frazier et al.
patent: 5314995 (1994-05-01), Fell, Jr. et al.
patent: 5336603 (1994-08-01), Capon et al.
patent: 5342604 (1994-08-01), Wilson et al.
patent: 5349052 (1994-09-01), Delgado et al.
patent: 5349053 (1994-09-01), Landolfi
patent: 5359046 (1994-10-01), Capon et al.
patent: 5399349 (1995-03-01), Paunescu et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5413923 (1995-05-01), Kucherlapati et al.
patent: 5427908 (1995-06-01), Dower et al.
patent: 5428139 (1995-06-01), Kiefer et al.
patent: 5435990 (1995-07-01), Cheng et al.
patent: 5436146 (1995-07-01), Shenk et al.
patent: 5441050 (1995-08-01), Thurston et al.
patent: 5447851 (1995-09-01), Beutler et al.
patent: 5460959 (1995-10-01), Mulligan et al.
patent: 5463575 (1995-10-01), White
patent: 5474981 (1995-12-01), Leder et al.
patent: 5478925 (1995-12-01), Wallach et al.
patent: 5480971 (1996-01-01), Houghten et al.
patent: 5489425 (1996-02-01), Kruper et al.
patent: 5505931 (1996-04-01), Pribish
patent: 5516637 (1996-05-01), Huang et al.
patent: 5530101 (1996-06-01), Queen et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5569825 (1996-10-01), Lonberg et al.
patent: 5571698 (1996-11-01), Ladner et al.
patent: 5573920 (1996-11-01), Randle
patent: 5580717 (1996-12-01), Dower et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5601819 (1997-02-01), Wong et al.
patent: 5605793 (1997-02-01), Stemmer
patent: 5612460 (1997-03-01), Zalipsky
patent: 5622929 (1997-04-01), Willner et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 5633425 (1997-05-01), Lonberg et al.
patent: 5641670 (1997-06-01), Treco et al.
patent: 5643575 (1997-07-01), Martinez et al.
patent: 5652361 (1997-07-01), Simon et al.
patent: 5658727 (1997-08-01), Barbas et al.
patent: 5661016 (1997-08-01), Lonberg et al.
patent: 5693622 (1997-12-01), Wolff et al.
patent: 5696239 (1997-12-01), Wilson et al.
patent: 5698426 (1997-12-01), Huse
patent: 5705151 (1998-01-01), Dow et al.
patent: 5714631 (1998-02-01), Wilson et al.
patent: 5733743 (1998-03-01), Johnson et al.
patent: 5750753 (1998-05-01), Kimae et al.
patent: 5756065 (1998-05-01), Wilson et al.
patent: 5766883 (1998-06-01), Ballance et al.
patent: 5780225 (1998-07-01), Wigler et al.
patent: 5807715 (1998-09-01), Morrison et al.
patent: 5808003 (1998-09-01), Subramanian et al.
patent: 5811097 (1998-09-01), Allison et al.
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5814318 (1998-09-01), Lonberg et al.
patent: 5821047 (1998-10-01), Garrard et al.
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5834252 (1998-11-01), Stemmer et al.
patent: 5837458 (1998-11-01), Minshull et al.
patent: 5876969 (1999-03-01), Fleer et al.
patent: 5885793 (1999-03-01), Griffiths et al.
patent: 5916771 (1999-06-01), Hori et al.
patent: 5939598 (1999-08-01), Kucherlapati et al.
patent: 5969108 (1999-10-01), McCafferty et al.
patent: 5985660 (1999-11-01), Galy
patent: 6075181 (2000-06-01), Kucherlapati et al.
patent: 6114598 (2000-09-01), Kucherlapati et al.
patent: 6599719 (2003-07-01), Yu et al.
patent: 6824767 (2004-11-01), Yu et al.
patent: 7597886 (2009-10-01), Yu et al.
patent: 2002/0111325 (2002-08-01), Li et al.
patent: 2003/0129189 (2003-07-01), Yu et al.
patent: 2005/0214305 (2005-09-01), Li et al.
patent: 2007/0297977 (2007-12-01), Yu et al.
patent: 196 39 601 (1997-09-01), None
patent: 0 173 494 (1986-03-01), None
patent: 0 239 400 (1987-09-01), None
patent: 0 282 317 (1988-09-01), None
patent: 0 307 434 (1989-03-01), None
patent: 0 367 166 (1990-05-01), None
patent: 0 394 827 (1990-10-01), None
patent: 0 396 387 (1990-11-01), None
patent: 0 401 384 (1990-12-01), None
patent: 0 413 622 (1991-02-01), None
patent: 0 439 095 (1991-07-01), None
patent: 0 322 094 (1992-02-01), None
patent: 0 506 477 (1992-09-01), None
patent: 0 519 596 (1992-12-01), None
patent: 0 171 496 (1993-05-01), None
patent: 0 592 106 (1994-04-01), None
patent: 0 682 110 (1995-11-01), None
patent: 0 399 816 (1995-12-01), None
patent: WO-86/01533 (1986-03-01), None
patent: WO-86/05807 (1986-10-01), None
patent: WO-87/01130 (1987-02-01), None
patent: WO-87/02671 (1987-05-01), None
patent: WO-87/04462 (1987-07-01), None
patent: WO-89/01036 (1989-02-01), None
patent: WO-89/02036 (1989-03-01), None
patent: WO-89/10404 (1989-11-01), None
patent: WO-89/12624 (1989-12-01), None
patent: WO-90/02809 (1990-03-01), None
patent: WO-90/11092 (1990-10-01), None
patent: WO-90/13649 (1990-11-01), None
patent: WO-91/00360 (1991-01-01), None
patent: WO-91/06570 (1991-05-01), None
patent: WO-91/06657 (1991-05-01), None
patent: WO-91/09967 (1991-07-01), None
patent: WO-91/10737 (1991-07-01), None
patent: WO-91/10741 (1991-07-01), None
patent: WO-91/14438 (1991-10-01), None
patent: WO-92/01047 (1992-01-01), None
patent: WO-92/05793 (1992-04-01), None
patent: WO-92/06180 (1992-04-01), None
patent: WO-92/06194 (1992-04-01), None
patent: WO-92/08495 (1992-05-01), None
patent: WO-92/08802 (1992-05-01), None
patent: WO-92/18619 (1992-10-01), None
patent: WO-92/22324 (1992-12-01), None
patent: WO-92/22635 (1992-12-01), None
patent: WO-93/11236 (1993-06-01), None
patent: WO-93/14188 (1993-07-01), None
patent: WO-93/17715 (1993-09-01), None
patent: WO-93/20221 (1993-10-01), None
patent: WO-93/21232 (1993-10-01), None
patent: WO-93/25788 (1993-12-01), None
patent: WO-94/08598 (1994-04-01), None
patent: WO-94/12649 (1994-06-01), None
patent: WO-94/12650 (1994-06-01), None
patent: WO-95/06058 (1995-03-01), None
patent: WO-95/15982 (1995-06-01), None
patent: WO-95/20401 (1995-08-01), None
patent: WO-96/04388 (1996-02-01), None
patent: WO-96/26736 (1996-09-01), None
patent: WO-96/29411 (1996-09-01), None
patent: WO-96/33735 (1996-10-01), None
patent: WO-96/34095 (1996-10-01), None
patent: WO-96/34096 (1996-10-01), None
patent: WO-96/39515 (1996-12-01), None
patent: WO-97/03394 (1997-01-01), None
patent: WO-97/33899 (1997-09-01), None
patent: WO-97/33904 (1997-09-01), None
patent: WO-97/34911 (1997-09-01), None
patent: WO-98/02543 (1998-01-01), None
patent: WO-98/06842 (1998-02-01), None
patent: WO-98/07832 (1998-02-01), None
patent: WO-98/07880 (1998-02-01), None
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