Methods for identifying an individual at increased risk of...

Chemistry: analytical and immunological testing – Process or composition for determination of physical state... – Corrosion resistance or power

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023100, C536S023500, C536S024310

Reexamination Certificate

active

07807465

ABSTRACT:
The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.

REFERENCES:
patent: 5449604 (1995-09-01), Schellenberg et al.
patent: 5508167 (1996-04-01), Roses et al.
patent: 5879884 (1999-03-01), Peroutka
patent: 5922556 (1999-07-01), Mayeux et al.
patent: 5958684 (1999-09-01), Van Leeuwen et al.
patent: 6027896 (2000-02-01), Roses et al.
patent: 6108635 (2000-08-01), Herren et al.
patent: 6165727 (2000-12-01), Lalouel et al.
patent: 6194153 (2001-02-01), St. George-Hyslop et al.
patent: 6342350 (2002-01-01), Tanzi et al.
patent: 2002/0037508 (2002-03-01), Cargill et al.
patent: 2003/0083485 (2003-05-01), Milos et al.
patent: 2004/0014109 (2004-01-01), Pericak-Vance et al.
patent: 2004/0053251 (2004-03-01), Pericak-Vance et al.
patent: 2004/0248092 (2004-12-01), Vance et al.
patent: 2005/0191652 (2005-09-01), Vance et al.
patent: 2006/0068428 (2006-03-01), Vance et al.
patent: 2006/0115845 (2006-06-01), Vance et al.
patent: 2007/0148661 (2007-06-01), Vance et al.
patent: 2009/0087844 (2009-04-01), Vance et al.
patent: 2009/0226420 (2009-09-01), Hauser et al.
patent: WO 99/57129 (1999-11-01), None
patent: WO 00/31253 (2000-06-01), None
patent: WO 01/20998 (2001-03-01), None
patent: WO 01/92576 (2001-12-01), None
patent: WO 02/02000 (2002-01-01), None
patent: WO 2004/005534 (2004-01-01), None
patent: WO 2004/007681 (2004-01-01), None
patent: WO 2007/086980 (2007-08-01), None
NCBI Database, National Center for Biotechnology Information, National Library of Medicine, NIH (Bethesda, MD, USA), rs1875518 (ss2752812) Jan. 2, 2001.
Hirschhorn et al. Genetics in Medicine. 2002. 4(2): 45-.
Halushka et al. Nature. Jul. 1999. 22: 239-247.
Brasch-Andersen et al. Journal of Medical Genetics. 2006. 43:e10.
Wu et al. Circulation. 2001. 103: 1386-1389.
Sanghera et al. Arteriosclerosis. 1997. 17: 1067-1073.
Abbas et al. “ A Wide Variety of Mutations in theParkinGene are Responsible for Autosomal Recessive Parkinsonism in Europe”Hum. Mol. Genet.8(4):567-574 (1999).
Amos “Robust Variance-Components Approach for Assessing Genetic Linkage in Pedigrees”Am J Human Genetics54:535-543 (1994).
Antonarakis et al. “Recommendations for a Nomenclature System for Human Gene Mutations”Human Mutation11:1-3 (1998).
Baker “Association of an extended haplotype in thetaugene with progressive supranuclear palsy”Hum. Mol. Genet.8(4):711-715 (1999).
Bengtsson et al. “Polymorphism in the β1-Adrenergic Receptor Gene and Hypertension”Circulation104:187-190 (2001).
Bertram et al. “No Association between marker D10S1423 and Alzheimer's Disease”Molecular Psychiatry8:571-573 (2003).
Bertram et al. “Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q”Science290:2302-2305 (2000).
Blacker et al. “Results of high-resolution genome screen of 437 Alzheimer's Disease families”Hum. Mol. Genet.12(1):23-32 (2003).
Blangero et al. “Multipoint Oligogenic Linkage Anaylsis of Quantitative Traits”Genetic Epidemiology14:959-964 (1997).
Board et al. “Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases”Journal of Biological Chemistry275(32):24798-24806 (2000).
Bouffard et al. GenBank Accession No. G20124. Sep. 28, 1998.
Boyles et al. “Linkage Disequilibrium Inflates Type 1 Error Rates in Multipoint Linkage Analysis when Parental Genotypes Are Missing”Hum Hered.59(4):220-227 (2005).
Specification for U.S. Appl. No. 10/520,695, filed Jan. 7, 2005.
Specification for U.S. Appl. No. 10/520,779, filed Jan. 7, 2005.
Corder et al. “Gene dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families”Science261(5123):921-923 (1993).
Daw et al. “Multipoint Oligogenic Analysis of Age-at-Onset Data with Applications to Alzheimer Disease Pedigrees”Am J Human Genetics64:839-851 (1999).
Daw et al. “The Number of Trait Loci in Late-Onset Alzheimer Disease”Am J Human Genetics66:196-204 (2000).
DeStefano et al. “Genome-Wide Scan for Parkinson's Disease: TheGenePD Study”Neurology57:1124-1126 (2001).
Dizier et al. “Genome screen for asthma and related phenotypes in the French EGEA study”American Journal Respiratory and Critical Care Medicine162:1812-1818 (2000).
Duggirala et al. “Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10g in Mexican Americans”Am J Human Genetics64:1127-1140 (1999).
Dulhunty et al. “The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator”Journal of Biological Chemistry276(5):3319-3323 (2001).
Ertekin-Taner et al. “Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees”Science290:2303-2304 (2000).
GenBank Accession No. rs4925, Reference SNP.
Goate et al. “Segregation of a Missense Mutation in the Amyloid Precursor Protein Gene with Familial Alzheimer's Disease”Nature349:704-706 (1991).
Goldgar “Mulitipoint Analysis of Human Quantitative Genetic Variation”Am J Human Genetics47:957-967 (1990).
Grover et al. “Effects on splicing and protein function of three mutations in codon N296 oftauin vitro”Neuroscience Letters323:33-36 (2002).
Hattori et al. “Point Mutations (Thr240Arg and Ala311Stop) in theParkinGene”Biochem. Biophys. Res. Commun.249:754-758 (1998).
Hiltunen et al. “Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer's disease patients”European Journal of Human Genetics7:652-658 (1999).
Hiltunen et al. “Linkage disequilibrium of Late-Onset Alzheimer's Disease at 13q12 Region”Society for Neuroscience24:1218m entry 478.4 (1998).
Hauser et al. “A Genomewide Scan for Early-Onset Coronary Artery Disease in 438 Families: The GENECARD study”Am. J. Hum. Genet.75:436-447 (2004).
International Search Report corresponding to PCT/US03/22259 dated Mar. 5, 2004.
International Search Report corresponding to PCT/US01/16940 dated Aug. 24, 2001.
International Search Report corresponding to PCT/US03/21963 dated Sep. 9, 2004.
International Search Report corresponding to PCT/US01/41224 dated Jan. 15, 2002.
Ioannidis et al. “Replication validity of genetic association studies”Nature Genetics29:306-309 (2001).
Kehoe et al. “A Full Genome Scan for Late Onset Alzheimer's Disease”Human Molecular Genetics8(2):237-245 (1999).
Khan et al. “Parkinson's Disease Is Not Associated With the Combined α-Synuclein/Apolipoprotein E Susceptibility Genotype”Annals of Neurology49(5):665-668 (2001).
Kitada et al. “Mutations in theparkingene cause autosomal recessive juvenile parkinsonism”Nature392:605-608 (1998).
Levy-Lahad et al. “Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus”Science269:973-977 (1995).
Li et al. “Modulation of Age at Onset and Risk in Alzheimer Disease” Abstract presented at American Society of Human Genetics Meeting, San Diego, CA Oct. 2001.
Li et al. “Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease”Human Molecular Geneti

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for identifying an individual at increased risk of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for identifying an individual at increased risk of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying an individual at increased risk of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4201223

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.