Tricyclic benzimidazole compounds, pharmaceutical compositions a

Details Tricyclic benzimidazole compounds, pharmaceutical compositions a Tricyclic benzimidazole compounds, pharmaceutical compositions a

1990-06-25

1992-05-26

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514254, 514267, 514293, 544 98, 544182, 544224, 544238, 544242, 544251, 544358, 544360, 546 82, A61K 31495, A61K 31415, C07D23700, C07D47102

Patent

active

051168430

ABSTRACT:
The present invention provides tricyclic benzimidazoles of the formula ##STR1## wherein R.sub.1 is a phenyl radical of the general formula: ##STR2## wherein R.sub.2, R.sub.3 and R.sub.4 can be the same or different as in claim 1. For A, B, C and D are understood those compounds where one or two of A, B, C or D are nitrogen. These compounds are useful to inhibit the aggregation of thrombocytes and erythrocytes, lower blood pressure and can increase the power of the heart.

REFERENCES:
Chemical Abstracts, 84:90072m Structure-activity relations of histamine analogs, 12. Imidazo [4.5-g] quinolines Lebenstedt et al. (1976).

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