Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-06-03
1989-01-24
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514336, 514357, 546264, 546284, 546334, 546335, C07D40112, A61K 3144
Patent
active
048002062
ABSTRACT:
Pyridine-ethanolamines of the formula ##STR1## wherein n, X, Y, R.sup.1, R.sup.2 and R.sup.3 have the significances given in the description, their corresponding enantiomers, diastereomers, and racemates as well as the pysiologically compatible salts thereof are describe. The compounds of formula I have catabolic activity and can be used for the treatment of obesity and of diabetes mellitus or of conditions which are associated with an increased protein breakdown, or as feed additives for fattening animals. The compounds of formula I can be prepared by alkylating the primary or secondary amines corresponding to the secondary or tertiary amines of formula I.
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patent: 4460580 (1984-07-01), Ostermayer et al.
Zymalkowski, F. et al., Synthesis of pyridine derivatives with potential circulatory system action, Arch. Pharm. 294, 453-468 (1961) CA 56:2415e.
L. Polo Friz, Nitrogen-substituted derivatives of 1-(4-pyridyl)-2-amino-ethanol Farmaco (Pana) Ed. Sci. 18(12), 972-980 (1963) CA 60:6815a.
Schultz, D. E., Synthesis of 1-(4-pyridyl)-2-amino-alkanol dihydrochlorides, Arch. Pharm. Ber. Deut. Pharm. Ger. 1972 305(4), 248-253 (Ger) CA 77:61749n.
Barth, W. E., 2-(hydroxymethyl)-3-hydroxy-6-(1-hydroxy-2-aminoethyl)pyridines, Ger. Offen. #2,204,195.
DT 2406-930 (U.S. Pat. No. 4,195,090) Derwent 61811V/35.
Alig Leo
Muller Marcel
Fan Jane T.
Hoffmann-La Roche Inc.
Isgro William G.
Leon Bernard S.
Saxe Jon S.
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